{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:43Z","timestamp":1783836463933,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170840"],"award-info":[{"award-number":["82170840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic foot ulcers (DFUs) complicated by multidrug\u2010resistant (MDR) bacterial infection present a significant clinical challenge that necessitates innovative therapeutic strategies. Conventional antimicrobial treatments often fail because of limited tissue penetration, antibiotic resistance, and poor efficacy against biofilm\u2010forming pathogens. In this study, we developed a near\u2010infrared (NIR) light\u2010responsive aggregation\u2010induced emission luminogen (AIEgen) with high photothermal conversion efficiency, excellent photostability, and favorable biocompatibility. Upon NIR light activation, this AIEgen can induce localized hyperthermia capable of disrupting bacterial membranes and penetrating deep into infected tissues, thereby effectively eradicating the embedded MDR pathogens and resilient biofilms. The antibacterial efficacy of the AIEgen was validated against MDR clinical isolates, including methicillin\u2010resistant Staphylococcus aureus (MRSA) and carbapenem\u2010resistant Pseudomonas aeruginosa (CRPA). In vitro and in vivo evaluations confirmed the potent bactericidal activity, efficient biofilm disruption ability, and minimal cytotoxicity of the AIEgen. Notably, in a DFU infection model, AIEgen administration and NIR light exposure significantly accelerated wound healing by eliminating pathogens, suppressing inflammation, promoting M2 macrophage polarization, enhancing collagen deposition, and stimulating angiogenesis. In conclusion, this AIEgen\u2010based photothermal system offers a noninvasive, biocompatible, and deeply penetrating antibacterial strategy for the treatment of chronic MDR infections in DFUs and has great potential for clinical translation.<\/jats:p>","DOI":"10.1002\/smll.202510741","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:07:51Z","timestamp":1769674071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["AIEgen\u2010Based Photothermal Nanoparticles With Dual Antibacterial and Anti\u2010Inflammatory Activities for Enhanced Healing of Infected Diabetic Wounds"],"prefix":"10.1002","volume":"22","author":[{"given":"Liwen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of Medicine Jiangmen Central Hospital  Jiangmen China"},{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lige","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Li","sequence":"additional","affiliation":[{"name":"Chronic Airways Diseases Laboratory Department of Respiratory and Critical Care Medicine Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Tropical Disease Research Department of Occupational Health and Medicine School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-4645","authenticated-orcid":false,"given":"Mengchen","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010020\u20100278\u20105"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02317-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115120"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(05)67700\u20108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1451"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5569"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.620"},{"key":"e_1_2_12_11_1","first-page":"61","article-title":"Effect of Extensive Debridement and Treatment on the Healing of Diabetic Foot Ulcers. Diabetic Ulcer Study Group","volume":"183","author":"Steed D. L.","year":"1996","journal-title":"Journal of the American College of Surgeons"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.045"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.095"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00618K"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411133"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00159"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.575"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045101\u20109"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120937"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122740"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.047"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416205"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c04026"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008071"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03925"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117130"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001553\u2010z"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15372"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c15216"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230024"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202108030"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.161664"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303967"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008802"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001035\u2010z"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04206"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304243"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122141"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411194"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300375"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S446911"},{"key":"e_1_2_12_44_1","article-title":"IWGDF\/IDSA Guidelines on the Diagnosis and Treatment of Diabetes\u2010Related Foot Infections (IWGDF\/IDSA 2023)","volume":"40","author":"Senneville E.","year":"2023","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00864"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306632"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.05.006"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305363"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122964"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20\u20100188"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201002737\u2010x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.315935"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010022\u201001013\u20102"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202510741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202510741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202510741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:27:00Z","timestamp":1783834020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202510741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":52,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/smll.202510741"],"URL":"https:\/\/doi.org\/10.1002\/smll.202510741","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10741"}}