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Traditional encapsulation strategies using either inorganic or organic materials face trade\u2010offs between moisture barrier performance and mechanical flexibility. Inorganic materials provide excellent moisture resistance but are brittle, whereas organic polymers are flexible but inherently permeable. Here, we developed a Multi\u2010layered Organic\u2010based Liquid Encapsulation (MOLE) specifically tailored for implantable bioelectronics. MOLE consists of a layer\u2010by\u2010layer assembly of amine\u2010functionalized silicone elastomer and Parylene\u2010C, forming chemically bonded and conformal interfaces with enhanced interfacial adhesion. The outermost silicone layer, infused with silicone oil, minimizes protein adsorption (&lt;1%), resists biofilm formation (sliding angle &lt;10\u00b0), and prevents adhesion of inflammatory cells and proteins, thereby reducing acute inflammation. This hybrid architecture achieves an 86\u2010fold improvement in adhesion strength compared to conventional Parylene\u2010C coatings and significantly enhances mechanical robustness under dynamic deformation. In addition, MOLE provides superior moisture and ion barrier properties. Accelerated aging tests at 85\u00b0C demonstrated a 160\u2010fold increase in insulation lifetime over Parylene\u2010C, equivalent to approximately 445 h at physiological temperature (37\u00b0C). Furthermore,\u00a0in vivo\u00a0studies using a degradable magnesium antenna demonstrated stable encapsulation, minimal interfacial disruption, and strong resistance to biological degradation over time.<\/jats:p>","DOI":"10.1002\/smll.202510949","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:25:43Z","timestamp":1769171143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanically Robust and Anti\u2010Biofouling Hybrid Encapsulation via Layered Organic\u2013Liquid Interfaces for Implantable Devices"],"prefix":"10.1002","volume":"22","author":[{"given":"Sangwoo","family":"Park","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Engineering 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University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung\u2010Ryul","family":"Ok","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"},{"name":"Division of Bio\u2010Medical Science and Technology KIST School Korea University of Science and Technology  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ryon","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  Cambridge Massachusetts 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