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Sonochemotherapy (SCT), which combines ultrasound\u2010triggered reactive oxygen species (ROS) generation with controlled drug release, presents a promising approach. Given the superficial anatomical location of the bladder, SCT's deep tissue penetration and favorable safety profile make it particularly suitable for bladder cancer treatment. However, SCT efficacy is frequently constrained by insufficient ROS production and sonosensitizer instability. To overcome these challenges, a MoN\/Au\/cTAT nanocomposite was developed by conjugating cisplatin and human immunodeficiency virus\u20101 transcription activator (cTAT) onto MoN\/Au nanosheets to enhance the stability and the effect of SCT. As a result, MoN\/Au\/cTAT demonstrates potent cytotoxicity against bladder cancer cells under ultrasound irradiation. In vivo, it effectively suppresses muscle\u2010invasive orthotopic bladder tumors while maintaining a high safety margin. In summary, the nanosonosensitizer\u2010chemodrug platform combines cTAT for improved transmucosal delivery and tumor penetration with MoN\/Au to efficiently generate ROS under ultrasound irradiation, offering a transformative strategy for muscle\u2010invasive bladder cancer therapy.<\/jats:p>","DOI":"10.1002\/smll.202511210","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:02:55Z","timestamp":1785139375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MoN\/Au\/cTAT Boosted Sonochemotherapy Post\u2010Intravesical Instillation in Bladder Cancer."],"prefix":"10.1002","volume":"22","author":[{"given":"Yunhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Imaging Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Department of Geriatrics Geriatric Hospital Affiliated to Wuhan University of Science and Technology  Wuhan 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