{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:12:47Z","timestamp":1793160767377,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX0394"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX0394"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304072"],"award-info":[{"award-number":["82304072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiation intestinal injury (RII) is a severe complication of abdominal and pelvic radiotherapy, driven by excessive reactive oxygen species (ROS), pyroptotic cell death, and gut microbiota dysbiosis. Conventional antioxidants are insufficient, as radical scavenging alone cannot suppress pyroptosis or restore immune\u2013microbiota balance. Herein, we developed a Pt\/Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanozyme\u2010curcumin co\u2010loaded multifunctional oral hydrogel (PMC@Gel), which integrates dual\u2010active catalysis and autophagy induction for comprehensive intervention. The heterostructured Pt\/Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanozyme exhibits a core\u2010satellite architecture with Pt\u2010O\u2010Mn interfacial bonds, enabling accelerated Mn redox cycling and complementary catalase\u2010 and SOD\u2010like activities for broad\u2010spectrum ROS elimination. These components were co\u2010encapsulated in a pH\u2010responsive sodium alginate\/sodium hyaluronate hydrogel, providing controlled intestinal release, strong mucosal adhesion, and prolonged retention. In vivo, PMC@Gel efficiently suppressed pyroptosis via ROS clearance, restored autophagy through curcumin, and reprogrammed the gut immune\u2013microbiota microenvironment, thereby alleviating inflammation and promoting epithelial repair. This work introduces a mechanistically integrated hydrogel that synergizes pyroptosis suppression with gut microenvironment reprogramming, offering a promising strategy for RII therapy and a paradigm for autophagy activation, gut microenvironment, nanozyme, pyroptosis, radiation intestinal injurymultifunctional nanozyme\u2010based materials in complex disease treatment.\n                  <\/jats:p>","DOI":"10.1002\/smll.202511251","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:04:47Z","timestamp":1769169887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifunctional Oral Hydrogel Containing Dual\u2010Active Pt\/Mn\n                    <sub>3<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    Nanozyme for Synergistic Pyroptosis Suppression and Gut Microenvironment Reprogramming to Alleviate Radiation Intestinal Injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology Southwest Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-9000","authenticated-orcid":false,"given":"Lei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cancer Center Chongqing Key Laboratory of Immunotherapy The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11121011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.717636"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100247\u20102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.10.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010020\u201001662\u20105"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119546"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00706"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020579"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13409"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2208506119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.11.023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000507\u20105"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124832"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010022\u201000909\u20101"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.718356"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001046\u20103"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.07.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116879"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.586392"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.115947"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.108309"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010018\u20100156\u20107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2022.101544"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119940"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106517"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE\u201022\u201000090.1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/nano.202000021"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101768"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307798"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210086"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001566"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.112580"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b01245"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308477"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303027"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035828\u20102"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.10.019"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100081"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010018\u20100003\u20104"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27404"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122791"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312275"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040794\u2010w"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c23142"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202511251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202511251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202511251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:11:17Z","timestamp":1774865477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202511251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":44,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/smll.202511251"],"URL":"https:\/\/doi.org\/10.1002\/smll.202511251","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"2025-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11251"}}