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Current treatment strategies primarily provide palliative care, with limited potential to alter disease progression or reverse tissue deterioration. Stem cell transplantation holds promising results. But poor cell retention and survival due to ROS and inflammation in OA lead to subpar therapeutic outcomes. In this study, we developed a dual\u2010network gelatin methacrylate (GelMA) and \u03ba\u2010carrageenan\u2010based injectable hydrogel loaded with antioxidant quercetin\u2010PLGA nanoparticles for stem cell delivery to treat OA. Physicochemical studies demonstrated stable gelation, controlled degradation, and self\u2010healing properties. In vitro studies revealed that the sustained release of quercetin effectively scavenged intracellular ROS, reduced the expression of pro\u2010inflammatory factors such as IL6, COX2, NF\u03ba\u03b2, and TNF\u03b1, and increased the expression of TGF\u03b2, IL4, SOX9, COL2, and ACAN, which are responsible for inflammation control and cartilage tissue regeneration. The sustained release of nanoparticles also enhanced the M1\u2010to\u2010M2 macrophage transition and collagen II deposition. In vivo studies demonstrated that the nanoparticle\u2010loaded stem cell\u2010encapsulated hydrogel increased glycosaminoglycan deposition, reduced inflammation, and improved joint mobility and cartilage repair. Thus, this antioxidant hydrogel\u2010based cell delivery system demonstrated suitability for OA therapy.<\/jats:p>","DOI":"10.1002\/smll.202511555","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:47:22Z","timestamp":1771602442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Quercetin Nanocarrier\u2010Loaded Dual Network Injectable Hydrogel for Mesenchymal Stem Cells (MSCs) Delivery Targeting Osteoarthritis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-5451","authenticated-orcid":false,"given":"Anwesha","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Indian Institute of Technology Ropar  Rupnagar Punjab 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