{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:38:18Z","timestamp":1792193898037,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370929"],"award-info":[{"award-number":["82370929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JYB2025XDXM610"],"award-info":[{"award-number":["JYB2025XDXM610"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010250","name":"Sichuan Province Youth Science and Technology Innovation Team","doi-asserted-by":"publisher","award":["2022JDTD0021"],"award-info":[{"award-number":["2022JDTD0021"]}],"id":[{"id":"10.13039\/501100010250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a leading cause of global disability, characterized by chronic inflammation, progressive cartilage degradation, and subchondral bone remodeling. While microRNAs (miRNAs) like miR\u2010143\u20103p show promising anti\u2010inflammatory and chondroprotective potential, their clinical application is hampered by poor stability and inefficient delivery. To address this, a vertex\u2010integrated tetrahedral DNA nanoframe (Tvi\u2010miR143) is developed for the stable and controlled delivery of miR\u2010143\u20103p. Tvi\u2010miR143 system uniquely integrates miR\u2010143 mimics within the DNA nanostructure, maintaining native tetrahedron geometry and facilitating controlled intracellular release via RNase H\u2010sensitive segments and toehold\u2010mediated strand displacement. Tvi\u2010miR143 exhibits physiological stability and efficient uptake by primary chondrocytes without transfection agents. In interleukin\u20101\u03b2 (IL\u20101\u03b2)\u2013stimulated chondrocytes, it reduces inflammation, oxidative stress, and apoptosis, while enhancing survival and matrix synthesis, outperforming free miR\u2011143, bare tetrahedral DNA nanostructures (TDN), and dexamethasone, a clinically used anti\u2010inflammatory drug. Mechanistically, Tvi\u2010miR143 inhibits NF\u2011\u03baB signaling, suppressing inflammatory cytokines and catabolic enzymes while upregulating cartilage matrix proteins. In an OA rat model, intra\u2011articular Tvi\u2011miR143 prolongs miRNA retention, preserves cartilage integrity, reduces matrix degradation, improves histological scores, and shows no systemic toxicity. These results highlight Tvi\u2011miR143 as an effective, stable, and biocompatible delivery platform that combines miR\u2010143 therapeutics with DNA nanotechnology, offering a promising strategy for OA therapy.<\/jats:p>","DOI":"10.1002\/smll.202511570","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:16:33Z","timestamp":1773216993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vertex\u2010Integrated Tetrahedral DNA Nanoframe Enhances miR\u2010143\u20103p Delivery for Osteoarthritis Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Xingyu","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wumeng","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[{"name":"Macao Translational Medicine Center Macau University of Science and Technology  Taipa Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-6561","authenticated-orcid":false,"given":"Yunfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases National Center for Stomatology West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University  Chengdu China"},{"name":"Sichuan Provincial Engineering Research Center of Oral Biomaterials  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(23)00163\u20107"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization Osteoarthritis (2023) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/osteoarthritis(accessed September 10 2025)."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001330\u2010w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010025\u201000594\u20106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010024\u201000375\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci113823"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00464.2022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010023\u201000611\u2010y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000805\u20100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010018\u20100045\u20107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707900105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504834102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MH00593K"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08195"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2012.0055"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945010791011938"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010021\u201008650\u20106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010017\u20104472\u20107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11780"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09\u20100881"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010025\u201003391\u2010x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.06.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010022\u201000104\u2010y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u20100090\u20108"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01406"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20105193(82)90002\u20109"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04586"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411118"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419914"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12917"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b17928"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010022\u201000212\u20101"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c17307"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403236"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010022\u201000171\u20107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123183"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2016.0633"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw236"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000251\u2010y"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(199802)41"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201096050\u20102"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(199809"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756\u2010185X.2010.01578.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1063\u20104584(03)00150\u2010x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21199"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.10.011"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.162"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085597"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11780"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010017\u20104472\u20107"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20124"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501401"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.014"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010024\u201001050\u20107"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406118"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202511570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202511570","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202511570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:17:28Z","timestamp":1781677048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202511570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":57,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/smll.202511570"],"URL":"https:\/\/doi.org\/10.1002\/smll.202511570","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11570"}}