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Proper care and control of\n                    <jats:italic>Candida<\/jats:italic>\n                    \u2010related infections are essential to prevent the emergence and spread of drug\u2010resistant strains, emphasizing the urgency of developing effective antifungal strategies. The ability of\n                    <jats:italic>Candida<\/jats:italic>\n                    to generate biofilms shields fungal cells from antifungal drugs, emphasizing the need for innovative therapeutic approaches. This study explores the synthesis of G4\u2010hydrogels through self\u2010assembly of guanosine nucleoside. The hydrogels are thermo\u2010reversible and demonstrate substrate\u2010induced modulation of mechanical properties, with the 2G hydrogel displaying superior performance. Circular dichroism experiments reveal the chirality of the molecular organization, correlating with gel stiffness. Furthermore, we report a hydrogel system having peroxidase mimicking activity via utilizing glucose oxidase and hemin. This system exhibits antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    in both planktonic and biofilm states. The current strategy has shown a reduction in fungal growth of 84% in planktonic state an\n                    <jats:italic>d<\/jats:italic>\n                    \u22484\u2010fold reduction in biofilm thickness as supported by in vitro experiments. In vivo studies on aneutrophilic mice validate the efficacy of the hydrogel system in inhibiting fungal growth and biofilm formation, highlighting its potential as a therapeutic strategy against pathogenic fungal pathogen\n                    <jats:italic>C albicans<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/smll.202511924","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:38:47Z","timestamp":1773304727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Substrate Induced Regulation of Rigidity of G4\u2010Hydrogels: Toward Peroxidase\u2010Mimic Facilitated Eradication of Fungi via Turning a Metabolic Friend to a Foe"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-2510","authenticated-orcid":false,"given":"Sayan","family":"Bera","sequence":"first","affiliation":[{"name":"School of Applied and 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