{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:24:51Z","timestamp":1786123491052,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinical translation of dissolving microneedles (DMNs) is hindered by critical challenges such as drug diffusion into the backing layer during fabrication and slow dissolution rates, which compromise dose accuracy, delivery efficiency, and user compliance. Although lyophilization has emerged as a strategy to accelerate microneedle dissolution by inducing a porous, amorphous microstructure, the resulting mechanical fragility limits effective skin insertion. To overcome these issues, we developed a Lyophilized Microneedle System using Biocompatible Glue (LMS\u2010BG), wherein a lyophilized, drug\u2010loaded microneedle tip is coupled with a prefabricated backing via a biodegradable, ethanol\u2010based glue (BC glue). This system enables tip\u2010localized drug confinement, rapid dissolution, and mechanical reinforcement through partial interpenetration of BC glue into the porous tip. Using lidocaine hydrochloride (LiH) as a model drug, LMS\u2010BG exhibited an 11\u2010fold faster dissolution rate than conventional DMNs, with over 96% of the drug retained in the tip and a transdermal delivery efficiency exceeding 90% within 2\u00a0min. In vivo studies in rats confirmed superior local anesthetic efficacy and biocompatibility of LMS\u2010BG compared to commercial lidocaine gel. Furthermore, the LMS\u2010BG fabrication method was successfully extended to various microneedle platforms using soluble polymers, hydrogels, and PLGA nanoparticles, demonstrating its scalability and versatility. Overall, the LMS\u2010BG platform addresses key translational barriers of conventional DMNs and presents a modular strategy for rapid, efficient, and clinically viable transdermal drug delivery.<\/jats:p>","DOI":"10.1002\/smll.202512379","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:14:22Z","timestamp":1770484462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biocompatible Glue\u2010Enabled Drug Localization and Mechanical Reinforcement of Lyophilized Microneedle Systems"],"prefix":"10.1002","volume":"22","author":[{"given":"Seon Tae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering Dankook University Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering Dankook University 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