{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:23:43Z","timestamp":1787585023241,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171354"],"award-info":[{"award-number":["32171354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bone defects arise from trauma, fractures, tumors, or infections, presenting significant treatment challenges. Effective repair requires concurrent angiogenesis and osteogenesis due to the importance of vasculature for nutrient supply. This study introduces a PDA@GelMA\/HA\u2010DA\/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    hydrogel, where Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ions crosslink dopamine\u2010modified hyaluronic acid (HA\u2010DA) with gelatin methacryloyl (GelMA) to form a dual\u2010network hydrogel, also incorporating photothermal polydopamine (PDA) nanoparticles. In vitro and in vivo studies reveal that Fe\n                    <jats:sup>3+<\/jats:sup>\n                    enhances angiogenesis, while the hydrogel's photothermal properties improve bone repair in massive defects. In cell experiments, bone marrow mesenchymal stem cells (BMSCs) exhibit the highest osteogenic differentiation in the hydrogel + photothermal group, followed by the hydrogel group alone. qPCR and Western blot analyses confirm elevated expression of osteogenic genes and proteins in BMSCs treated with the hydrogel + photothermal method. Micro\u2010computed tomography (Micro\u2010CT) analyses show the most significant bone formation in the hydrogel + photothermal group, while control samples show limited mineralization. Histological staining indicates substantial bone tissue formation in the treatment groups, with increased expression of osteogenesis\u2010related proteins (OCN, OPG, RUNX2, ALP) and angiogenesis markers (CD31, VEGFA). Our study demonstrates that the PDA@GelMA\/HA\u2010DA\/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    hydrogel promotes bone defect repair, with Fe\n                    <jats:sup>3+<\/jats:sup>\n                    mediating angiogenic effects and photothermal stimulation augmenting its osteogenic potential.\n                  <\/jats:p>","DOI":"10.1002\/smll.202512528","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:33:06Z","timestamp":1769167986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mild Photothermal Stimulation Driven Nanoparticles Hybrid Dual\u2010Network Hydrogels for Bone Repair"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiuwen","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanrong","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxian","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research 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