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Herein, we report the development of a microgel\u2010integrated microneedle array patch (MI\u2010MAP) capable of not only localizing protein cargoes in the tip portion but also stabilizing them via protein\u2010phenolic interactions. Incorporation of protein\u2010capturing microgels allows enrichment of protein cargoes within the tip region of microneedles, resulting in a significant enhancement in their transdermal delivery performance. MI\u2010MAP enables more effective stabilization of labile recombinant proteins, such as botulinum neurotoxin, human interferon alpha\u20102a, and SARS\u2010CoV\u20102 spike receptor\u2010binding domain (RBD), during storage at 25 \u00b0C for 28 days compared to the counterpart lacking the microgels (HA\u2010MAP). Transdermal delivery of CpG\u2010adjuvanted RBD using MI\u2010MAP elicits a more rapid neutralizing antibody response and germinal center B\u2010cell proliferation in mice than HA\u2010MAP and subcutaneous injection, without causing any severe inflammation. This study presents a potential strategy for improving tip\u2010loading and storage stability of recombinant proteins within microneedle structures.<\/jats:p>","DOI":"10.1002\/smll.202512624","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:36:44Z","timestamp":1769168204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protein\u2010Capturing Microgel\u2010Integrated Microneedle Array Patches for Enhanced Tip\u2010Loading, Storage Stability, and Transdermal Delivery of Recombinant Proteins"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8987-879X","authenticated-orcid":false,"given":"Ki Hyun","family":"Bae","sequence":"first","affiliation":[{"name":"Bioprocessing Technology Institute (BTI) Agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-9362","authenticated-orcid":false,"given":"Kun","family":"Liang","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University (NTU)  Singapore Republic of Singapore"},{"name":"A*STAR Skin Research Labs (A*SRL) Agency for Science Technology and Research (A*STAR) &amp; Skin Research Institute of Singapore (SRIS)  Singapore 308232 Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon Y. 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