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In this work, a multiple interface\u2010based confinement strategy was demonstrated to simultaneously boost photoelectrochemical (PEC) and electrochemiluminescence (ECL) responses for acetamiprid detection accompanying with intramolecular DNA wheel nanostructures as signal amplification and PtPd\u2010CoSnO\n                    <jats:sub>3<\/jats:sub>\n                    nanocubes as quenchers. Due to the confinement effect and multiple light reflections between CdS nanoparticles, SiO\n                    <jats:sub>2<\/jats:sub>\n                    , and NaYF\n                    <jats:sub>4<\/jats:sub>\n                    :Yb\/Tm, CdS@SiO\n                    <jats:sub>2<\/jats:sub>\n                    @NaYF\n                    <jats:sub>4<\/jats:sub>\n                    :Yb\/Tm core\u2013shell nanocomposites possessed fast electron transfer and high light utilization, yielding enhanced PEC and ECL responses. The peroxidase\u2010mimicking catalytic precipitation property and the broad\u2010spectrum absorption of PtPd\u2010CoSnO\n                    <jats:sub>3<\/jats:sub>\n                    nanocubes realized the simultaneous quench of PEC and ECL signals. Impressively, nicking endonuclease (NEase)\u2010based DNA wheel nanostructures were quite beneficial to the low background interference and the efficient dynamic signal amplification. As a result, the proposed dual\u2010mode biosensor achieved acetamiprid detection in a range of 1 fM to 1 nM with detection limit of 0.31 fM (PEC detection) and 0.42 fM (ECL detection). Moreover, satisfactory results were also obtained in the analysis of real samples with remarkable selectivity, stability and reproducibility, establishing the biosensor as a dependable approach for precise pesticides detection.\n                  <\/jats:p>","DOI":"10.1002\/smll.202512985","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:28:02Z","timestamp":1769005682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Confinement of Multiple Interfaces for Self\u2010Enhanced Photoelectrochemical and Electrochemiluminescence Dual\u2010Mode Biosensor"],"prefix":"10.1002","volume":"22","author":[{"given":"Yao","family":"Song","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Science Jiangsu Normal University  Xuzhou Jiangsu 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