{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:38:12Z","timestamp":1782902292493,"version":"3.54.5"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In vitro fertilization (IVF) requires repeated bolus injections of gonadotropins at precise times, making it a painful and stressful experience for women. Polymeric microneedles (MNs) present a painless alternative to hypodermic needles, but controlling the release of drugs through MNs remains a challenge. Here, we report the development of a hydrogel MN patch integrated with upconverting nanoparticles coated with light\u2010breakable mesoporous silica (UCNP@LBMS) that releases the IVF gonadotropin, leuprolide, in response to near\u2010infrared (NIR) light, while retaining the UCNPs within the MN patch. In rats, a 5\u00a0min NIR pulse of 2\u00a0W\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    results in a significant increase in leuprolide release in both skin and plasma, with MN length playing an important role in drug bioavailability. Beyond IVF, UCNP\u2010integrated MN patches offer a painless, automated alternative in any application that requires daily, repeated, time\u2010sensitive hypodermic needle injections, such as diabetes or multiple sclerosis.\n                  <\/jats:p>","DOI":"10.1002\/smll.202513138","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:50:44Z","timestamp":1763646644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Upconverting Nanoparticle\u2010Loaded Microneedles for Near\u2010Infrared Responsive Delivery of Gonadotropins to Increase Success of In Vitro Fertilization"],"prefix":"10.1002","volume":"22","author":[{"given":"Vivienne","family":"Tam","sequence":"first","affiliation":[{"name":"Mining and Materials Engineering McGill University  3610 Rue University Montreal Quebec H3A 0C5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusvir","family":"Trana","sequence":"additional","affiliation":[{"name":"Bioengineering McGill University  3480 Rue University Montreal Quebec H3A 0E9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Nieto\u2010Arguello","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montreal  2940 chemin de Polytechnique Montreal Quebec H3T 1J4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ore\u2010Oluwa","family":"Olasubulumi","sequence":"additional","affiliation":[{"name":"Bioengineering McGill University  3480 Rue University Montreal Quebec H3A 0E9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Babity","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montreal  2940 chemin de Polytechnique Montreal Quebec H3T 1J4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artiom","family":"Skripka","sequence":"additional","affiliation":[{"name":"Department of Chemistry Oregon State University  Corvallis Oregon 97331 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Vetrone","sequence":"additional","affiliation":[{"name":"Centre \u00c9nergie Mat\u00e9riaux et T\u00e9l\u00e9communications Institut National de la Recherche Scientifique Universit\u00e9 du Qu\u00e9bec  1650 Boul. Lionel Boulet Varennes Qu\u00e9bec J3X 1P7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montreal  2940 chemin de Polytechnique Montreal Quebec H3T 1J4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-3071","authenticated-orcid":false,"given":"Marta","family":"Cerruti","sequence":"additional","affiliation":[{"name":"Mining and Materials Engineering McGill University  3610 Rue University Montreal Quebec H3A 0C5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_9_1_1","author":"Farquhar C.","year":"2018","journal-title":"Cochrane Database Syst. 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