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While reperfusion restores blood flow, it does not mitigate oxidative stress and inflammation that worsen injury, and conventional anti\u2010inflammatories risk systemic immunosuppression. Here, we developed manganese\u2010doped Ag\n                    <jats:sub>2<\/jats:sub>\n                    Te quantum dots (Mn: Ag\n                    <jats:sub>2<\/jats:sub>\n                    Te QDs) surface\u2010modified with tannic acid (TA) to achieve myocardial\u2010targeted therapy, real\u2010time visualization of drug distribution, and post\u2010treatment verification. Mn doping endows enzyme\u2010mimetic antioxidant activity, enabling efficient scavenging of ROS to alleviate oxidative stress and dampen inflammatory signaling, including cGAS\u2013STING\u2010 and ZBP1\u2010associated pathways. TA confers strong cardiac affinity, enhancing selective accumulation in infarcted myocardium. The QDs emit in the NIR\u2010IIb window, allowing deep\u2010tissue, high\u2010contrast, real\u2010time fluorescence imaging for noninvasive monitoring of biodistribution and targeted delivery. In vitro and in vivo studies demonstrate robust ROS clearance, reduced inflammation, and improved cardiac function, with favorable biocompatibility and safety. This integrated platform unites myocardial targeting, ROS scavenging, and NIR\u2010IIb imaging, offering a promising approach for the precision treatment of AMI.\n                  <\/jats:p>","DOI":"10.1002\/smll.202513213","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:35:16Z","timestamp":1778837716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myocardium\u2010Targeted Near Infrared\u2010IIb Emitting Atomically Dispersed Catalysts for ROS Scavenging in Acute Myocardial Infarction"],"prefix":"10.1002","volume":"22","author":[{"given":"Shuli","family":"Bi","sequence":"first","affiliation":[{"name":"School of Medicine Nankai University  Tianjin P. R. China"},{"name":"Department of Cardiology Tianjin Union Medical Center The First Affiliated Hospital of Nankai University  Tianjin P. R. 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