{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:25:12Z","timestamp":1791379512091,"version":"4.3.3"},"reference-count":64,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peptide\u2010based self\u2010assembled nanostructures offer great promise for targeted drug delivery due to their intrinsic biocompatibility, biodegradability, and structural tunability. However, their limited optical properties and lack of functional sites for selective targeting restrict their use in theranostics. Here, we report a fluorophore\u2010integrated, pH\u2010responsive dipeptide nanocarrier engineered from phenylalanine\u2013tryptophan (F\u2013W) conjugated with 4\u2010chloro\u20107\u2010nitrobenzofurazan (NBD) as a fluorescent probe and vitamin B6 (VitB6) as a pH\u2010sensitive unit. The resulting vitamin B6\u2010modified nanoparticles (\n                    <jats:bold>PS\u2010Dox<\/jats:bold>\n                    ) exhibited charge reversal from negative to positive under mildly acidic conditions (pH 5.0), promoting doxorubicin (Dox) release, endosomal escape, and nuclear localization.\n                    <jats:bold>PS\u2010Dox<\/jats:bold>\n                    demonstrated enhanced cytotoxicity, DNA damage, and apoptosis induction in multiple cancer cell lines, while showing negligible toxicity toward non\u2010malignant cardiomyocytes (AC\u201016 and H9C2).\n                    <jats:italic>In vivo<\/jats:italic>\n                    biodistribution and pharmacokinetic studies revealed increased tumour accumulation and superior tumour growth inhibition compared with Dox. Importantly,\n                    <jats:bold>PS<\/jats:bold>\n                    \u2010mediated encapsulation effectively mitigated Dox\u2010associated cardiotoxicity, a major limitation of conventional chemotherapy. Overall, this study establishes a vitamin B6\u2010mediated, charge\u2010reversible peptide nanocarrier as a biocompatible and efficient platform for targeted anticancer drug delivery, combining tumour\u2010specific therapeutic efficacy with improved cardiac safety.\n                  <\/jats:p>","DOI":"10.1002\/smll.202513436","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:54:31Z","timestamp":1770483271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NBD Integrated and Vitamin B6\u2010Driven Charge\u2010Reversible Peptide\u2010Based Nanocarriers for Targeted Therapeutic Delivery"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5381-5777","authenticated-orcid":false,"given":"Suman","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Chennai 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College of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-5384","authenticated-orcid":false,"given":"Gaurav","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Signal Transduction and Biogenic Amines Chittaranajan National Cancer Institute  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswanath","family":"Maity","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bose Institute Unified Academic Campus  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-6660","authenticated-orcid":false,"given":"Priyadip","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Chennai 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