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However, how to enhance the antigen presentation efficiency of mRNA\u2010encoded tumor antigens and the intensity of vaccine\u2010induced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell response remains a great challenge. In this study, an antigen\u2010angiotensin II (ANG II) fusion mRNA nanovaccine that can enhance the immunogenicity of tumor antigens to promote CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell immunity for effective tumor inhibition is developed. Furthermore, this mRNA nanovaccine is delivered by lipid nanoparticles (LNPs) composed of cationic lipid\u2010like material C1 and L\u2010phenylalanine\u2010based poly (ester amide) 8p4, which promotes the maturation of dendritic cells (DCs) and increases the type 1 conventional DC (cDC1) subpopulation, together enhancing the antigen presentation function of DCs for eliciting potent antigen\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell response. Vaccination with the antigen\u2010ANG II mRNA nanovaccine expressing different tumor antigens effectively inhibited tumor growth on multiple mouse tumor models, which was greatly compromised in the cDC1\u2010deficient\n                    <jats:italic>Batf3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Overall, this work provides an antigen\u2010ANG II fusion mRNA tumor nanovaccine platform with remarkable antitumor efficacy via triggering cDC1\u2010mediated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell response.\n                  <\/jats:p>","DOI":"10.1002\/smll.202513524","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:25:08Z","timestamp":1777307108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An mRNA Tumor Nanovaccine Expressing Tumor Antigen Fused With Angiotensin II Facilitates Type 1 Conventional Dendritic Cell\u2010Mediated Anti\u2010Tumor Immunity"],"prefix":"10.1002","volume":"22","author":[{"given":"Chunyuan","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou 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