{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:31:55Z","timestamp":1784075515813,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX0554"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX0554"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The excessive generation of reactive oxygen species (ROS) and its synergistic interplay with inflammation and apoptosis play a critical role in the progression of drug\u2010induced liver injury (DILI). Ceria nanoparticles are potential DILI therapy candidates due to their self\u2010renewable ROS scavenging activity. However, the clinical translation of ceria nanoparticles for DILI therapy is challenged by enhanced ROS scavenging activity and prolonged hepatic retention. Herein, the sulfur\u2010fumigation approach is used to modulate the ROS scavenging activity of ceria nanoparticles through the surface microstructure reconfiguration mechanism. The sulfur\u2010fumigation induces nanoparticle contraction and crystalline fusion. Crucially, sulfur\u2010fumigation decreases (111) plane exposure but increases (200) and (220) plane exposure. These changes cause the generation of abundant oxygen vacancies, which significantly enhances the ROS scavenging activity of ceria nanoparticles, even when the surface area is decreased. Together with an appropriate hydrodynamic diameter (135.9\u00a0nm) for liver targeting, the sulfur\u2010fumigated ceria nanoparticles can easily accumulate in the liver and alleviate ROS, inflammation, and apoptosis in DILI mice. Compared to the clinical standard N\u2010acetylcysteine (NAC), the sulfur\u2010fumigated ceria nanoparticles show better therapeutic efficacy across most of the detected parameters. These findings suggest that sulfur\u2010fumigation is a potent surface reconfiguration strategy to engineer highly active ceria nanoparticles for DILI therapy.<\/jats:p>","DOI":"10.1002\/smll.202513609","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:53:21Z","timestamp":1769673201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sulfur\u2010Fumigation Engineered Ceria Nanoparticles With Augmented Oxygen Vacancies for Enhanced Therapy of Drug\u2010Induced Liver Injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Run","family":"Huang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Medical Imaging Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing General Hospital Chongqing 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