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Early surgical resection remains the most promising curative approach; however, approximately 90% of patients are diagnosed at an advanced stage due to its insidious onset and rapid metastasis. Currently, anatomical imaging techniques such as endoscopic ultrasound, computed tomography, and magnetic resonance imaging (MRI) have limited sensitivity and specificity for detecting small and early\u2010stage lesions of PC. Molecular probes, which selectively bind to specific molecular targets, enable the visualization of molecular and cellular abnormalities and hold significant potential for tumor detection and staging. This review focuses on recent advances in molecular imaging strategies for the detection of PC, providing a systematic overview of novel probes used in MRI, PET, fluorescence, and dual\u2010\/multi\u2010modal imaging techniques. 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