{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:34:05Z","timestamp":1792175645184,"version":"4.4.0"},"reference-count":292,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370929 82501114"],"award-info":[{"award-number":["82370929 82501114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2024M762233"],"award-info":[{"award-number":["2024M762233"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010250","name":"Sichuan Province Youth Science and Technology Innovation Team","doi-asserted-by":"publisher","award":["2022JDTD0021"],"award-info":[{"award-number":["2022JDTD0021"]}],"id":[{"id":"10.13039\/501100010250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In recent years, the incidence and complexity of autoimmune diseases (AIDs) have been steadily increasing, posing grim challenges to clinical management. These diseases often involve multi\u2010organ dysfunction and impose a pronounced burden on patients' physical and mental health. Current therapeutic strategies remain suboptimal, frequently limited by poor specificity and severe systemic side effects. With the rapid advancement of nanotechnology, nanodrugs have emerged as a potential approach on account of their enhanced targeting capability, high therapeutic efficacy, and reduced toxicity. In particular, macrophage\u2010targeted nanodrugs have gained considerable attention, given that macrophages act as a key mediator in the onset and progression of various AIDs. This review systematically summarizes the molecular basis of macrophage involvement in autoimmunity, the design strategies of nanodrugs, and their applications across different AIDs, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis (PSO), and systemic lupus erythematosus (SLE). These nanodrugs exert their therapeutic effects primarily by modulating macrophage\u2010mediated immune responses, specifically through reprogramming macrophage phenotypes to promote anti\u2010inflammatory and tissue\u2010reparative functions. By precisely reprogramming macrophage function, these nanotherapeutics offer a novel approach for AID treatment.<\/jats:p>","DOI":"10.1002\/smll.202513797","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T11:36:21Z","timestamp":1770377781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanomedicine Strategies for Autoimmune Diseases: Targeting and Reprogramming Macrophages"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhongyi","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggao","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliu","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4652-6918","authenticated-orcid":false,"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-6561","authenticated-orcid":false,"given":"Yunfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103236"},{"key":"e_1_2_11_3_1","volume-title":"Enhancing NIH Research on Autoimmune Disease","author":"National Academies of Sciences, Engineering, and Medicine","year":"2022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199651030\u201000007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.09.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010210715"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000164"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001952\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010020\u201000810\u20102"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100939\u20108"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010023\u201000769\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010093019\u2010110159"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.11.024"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.03.030"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010024\u201000866\u2010z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000790\u20108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010022\u201000841\u2010w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1352946"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.867260"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3469"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70305\u20109"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.034"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.136"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200019c"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.10.022"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312169"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403409"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010021\u201000629\u2010x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.08.001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010018\u20100392\u20108"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c11858"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001319\u20107"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S361400"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.12.003"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07843"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12224"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1160719"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.054"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602325"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100897"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13181586"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006002\u2010x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S423819"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.016"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim\u20102023\u20100123"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(97)70030\u20101"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.05.025"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.941071"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.734008"},{"issue":"69","key":"e_1_2_11_56_1","first-page":"151","article-title":"Macrophage Subpopulations in Systemic Lupus Erythematosus","volume":"13","author":"Orme J.","year":"2012","journal-title":"Discovery Medicine"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1394108"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.09.001"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3796"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1603547"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.009"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18865"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202514713"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.adl2007"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001759\u20102"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08785"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302331"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103574"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18099"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002540\u20102"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.04.012"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101792"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003389\u20109"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123006"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03726"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113774"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.12.034"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500883"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.005"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13139"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01462"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1482728"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01452-1"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225433"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3120391"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.019"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010024\u201001865\u20105"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415265"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121457"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201700290"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.790963"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.072"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010014\u20108451\u2010x"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010095"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406877"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137102"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119730"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120884"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.09.012"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020162"},{"key":"e_1_2_11_102_1","first-page":"4911","article-title":"Co\u2010ASSOCiation of Methotrexate and SPIONs INTO anti\u2010CD64 AntiboDY\u2010CONJUGAted PLGA Nanoparticles for Theranostic Application","volume":"9","author":"Moura C. C.","year":"2014","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202500113"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.005"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn505634h"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036625\u20107"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.02.073"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.03.006"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2024.100885"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121930"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140399"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03991"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c09842"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120390"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.11.020"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2024.2380538"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c04491"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202412491"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002645\u20108"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.029"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304610"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03828"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300678"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416265"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001447\u20100"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302503"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe0083"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1616"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0164-y"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.877442"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.054"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301670"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S438388"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122706"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003399"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202100130"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b02919"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.021"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304006"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.04.027"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4053"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114614"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.002"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.030"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.12.024"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003110\u2010w"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400679"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010018\u20100382\u2010x"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.030"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.060"},{"key":"e_1_2_11_151_1","first-page":"416","article-title":"Nanoparticle Interactions With the Immune System: Clinical Implications for Liposome\u2010Based Cancer Chemotherapy","volume":"8","author":"La\u2010Beck N. M.","year":"2017","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.12.023"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04586"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.11.006"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010020\u20100355\u2010z"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410162"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411740"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010022\u201000171\u20107"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13470"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13637"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22579"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202310749"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.12.015"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.09.004"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010024\u201000319\u20107"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001736\u20100"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.10.069"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407458"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001570"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609397113"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.16"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202300097"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002374\u2010y"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c13261"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125816"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.18433\/J31021"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42247-021-00335-x"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2021.1912008"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118859"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c00355"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202408205"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035828\u20102"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121018"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001654\u20107"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03886"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00178C"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01029"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001438\u20101"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S462480"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.12.012"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2094364"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c11494"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c02768"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309026"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010020\u201000606\u2010z"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118612"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122505"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3622"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001704\u20100"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.026"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.019"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100799"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002711\u20101"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21945"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.97096"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2400194121"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308325"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2024.101012"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114618"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S382252"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002784\u2010y"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.02.017"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130227"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123501"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202424409"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002558\u20106"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002877\u20108"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.005"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010018\u20101008\u20104"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.056"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202403579"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01976-2"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.026"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21767"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2023.103043"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.90246"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2019.2894713"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.08.015"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c06627"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04510"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1907646116"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c02186"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3661"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00184\u20107"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.158"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)30173\u20108"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102741"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.07.026"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.05.192"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.013"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.81"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn500685h"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00464"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00368"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32448\u20100"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.09.019"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1954"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.02.012"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401869"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.001"},{"key":"e_1_2_11_253_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.88"},{"key":"e_1_2_11_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108176"},{"key":"e_1_2_11_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101945"},{"key":"e_1_2_11_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.10.001"},{"key":"e_1_2_11_257_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"e_1_2_11_258_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05544"},{"key":"e_1_2_11_259_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002725\u20109"},{"key":"e_1_2_11_260_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712946114"},{"key":"e_1_2_11_261_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.033"},{"key":"e_1_2_11_262_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201003007\u20100"},{"key":"e_1_2_11_263_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001133"},{"key":"e_1_2_11_264_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2023.2245332"},{"key":"e_1_2_11_265_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_2_11_266_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c00946"},{"key":"e_1_2_11_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.12.195"},{"key":"e_1_2_11_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.054"},{"key":"e_1_2_11_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.05.013"},{"key":"e_1_2_11_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)61909\u20107"},{"key":"e_1_2_11_271_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4756"},{"key":"e_1_2_11_272_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"e_1_2_11_273_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002986\u20104"},{"key":"e_1_2_11_274_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053396\u2010x"},{"key":"e_1_2_11_275_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13533"},{"key":"e_1_2_11_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.032"},{"key":"e_1_2_11_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101875"},{"key":"e_1_2_11_278_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1118180"},{"key":"e_1_2_11_279_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832e977c"},{"key":"e_1_2_11_280_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010018\u20100872\u2010z"},{"key":"e_1_2_11_281_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201003174\u20107"},{"key":"e_1_2_11_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01126\u20101"},{"key":"e_1_2_11_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103276"},{"key":"e_1_2_11_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103109"},{"key":"e_1_2_11_285_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010070119\u2010115617"},{"key":"e_1_2_11_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2025.103820"},{"key":"e_1_2_11_287_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002124\u2010y"},{"key":"e_1_2_11_288_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2018.1420053"},{"key":"e_1_2_11_289_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010022\u201006942\u20103"},{"key":"e_1_2_11_290_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00080\u20107"},{"key":"e_1_2_11_291_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306081"},{"key":"e_1_2_11_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"e_1_2_11_293_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2315"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202513797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202513797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202513797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:47:29Z","timestamp":1774716449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202513797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":292,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/smll.202513797"],"URL":"https:\/\/doi.org\/10.1002\/smll.202513797","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13797"}}