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However, most probiotics could not survive when exposed to the acidic stomach condition after oral administration, imposing a significant barrier to their broad applications. Here, a water\u2010in\u2010oil jammed Pickering emulsion gel (JPEG) is prepared to encapsulate probiotics, which effectively protects probiotics from the harsh acidic condition and specifically releases them in the intestine. Probiotics\u2010loaded JPEG (PL\u2010JPEG) demonstrates good stability against centrifugation forces, pH changes, temperature changes, and over time, and shows good processability with a typical shear\u2010thinning behavior. PL\u2010JPEG could be encapsulated in core\u2013shell microparticles by microfluidics to facilitate oral administration. Cell viability and optical density measurements confirm that the continuous oil phase of PL\u2010JPEG could protect probiotics from direct contact with the acidic stomach condition, leading to a significant improvement in their survival rate as compared to unencapsulated probiotics. Probiotics are then released in the intestine through an enzyme\u2010triggered mechanism, as the continuous oil phase is digested by lipase. The study successfully develops a probiotics\u2010loaded emulsion gel system, offering a promising platform for the intestine\u2010specific delivery of probiotics in functional foods and pharmaceutical formulations.<\/jats:p>","DOI":"10.1002\/smll.202513902","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:41:13Z","timestamp":1776847273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emulsion Gel for Intestine\u2010Specific Enzyme\u2010Triggered Release of Probiotics"],"prefix":"10.1002","volume":"22","author":[{"given":"Baoling","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Oncology Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"},{"name":"Department of Oncology Molecular Oncology Research Institute The First Affiliated Hospital Fujian Medical University  Fuzhou Fujian 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