{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:46:55Z","timestamp":1789523215983,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1210004"],"award-info":[{"award-number":["2024YFA1210004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["F251001"],"award-info":[{"award-number":["F251001"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a prevalent chronic inflammatory disease driven by bacterial infection, whose treatment remains challenging due to persistent inflammation and limited tissue regeneration. Here, we developed an injectable and thermosensitive hydrogel (Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @Gel) composed of hyaluronic acid\/Pluronic\u00a0F127 and Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    nanorods (Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    NDs), which synergistically combines antibacterial and anti\u2010inflammatory functions. Under near\u2011infrared (NIR) irradiation, Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @Gel exhibits excellent photothermal properties. It generates mild hyperthermia while simultaneously amplifying reactive oxygen species (ROS) and depleting glutathione (GSH), leading to effective bacterial eradication. Simultaneously, the hyaluronic acid matrix prolongs local retention, suppresses M1 macrophage polarization, and promotes tissue repair. In vitro studies confirm favorable biocompatibility, potent antibacterial activity, and effective immunomodulation. In vivo, Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @Gel accelerates diabetic wound healing and promotes periodontal regeneration comparable to minocycline treatment, as evidenced by reduced inflammation, enhanced collagen deposition, and significant alveolar bone restoration. Collectively, Bi\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    @Gel integrates antibacterial, anti\u2011inflammatory, and regenerative capabilities, offering a promising therapeutic platform for periodontitis and other chronic infectious diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.202513986","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:09:13Z","timestamp":1770116953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Injectable Thermogel\u2010Loaded Bi\n                    <sub>2<\/sub>\n                    S\n                    <sub>3<\/sub>\n                    Nanorods for Synergistic Photothermal Bacterial Elimination and Anti\u2011Inflammation to Remodel Periodontitis Microenvironment"],"prefix":"10.1002","volume":"22","author":[{"given":"Shuo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fene","family":"Gao","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory CAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety &amp; CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Third Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Southern Medical Branch of PLA General Hospital  Beijing China"},{"name":"PLA Medical School  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Medical Center Chinese PLA General Hospital  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