{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:57:36Z","timestamp":1781524656806,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403189"],"award-info":[{"award-number":["52403189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Biomedical patches provide promising tactics for promoting wound healing. The primary challenge is to develop biologically derived patches that more accurately mimic the physiological environment to enhance therapeutic efficacy. Here, we propose a decellularized freeze\u2010dried tumor (dFCT) tissues derived bio\u2010patch incorporated with hair melanin nanoparticles (HNPs) for wound healing. The HNPs are derived from human black hair, endowing the bio\u2010patches with natural reactive oxygen species scavenging capability and photothermal\u2010responsive antibacterial property. After removing tumor cells from colon tumor tissue through classic decellularization and using the freeze\u2010drying approach, the decellularized colon tumor tissues effectively retain the extracellular matrix nutrients including growth factors, collagen and fibrin. The resultant dFCT tissues loaded HNPs\u2010GelMA hydrogel (dFCT\u2010HNPs\u2010GelMA) bio\u2010patches are prone to promote cell growth, migration, and angiogenesis in vitro. Owing to these advantages, the bio\u2010patches significantly accelerate in vivo wound healing by reducing oxidative stress, suppressing inflammation and promoting angiogenesis. Thus, we believe that the proposed dFCT\u2010HNPs\u2010GelMA bio\u2010patches can be optimal naturally multifunctional medical patches for refractory wound healing management.<\/jats:p>","DOI":"10.1002\/smll.202514483","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:26:17Z","timestamp":1775204777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Freeze\u2010Drying Tumor Tissues Derived Bio\u2010Patches With Hair Melanin Nanoparticles Integration for Wound Healing"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4293-9345","authenticated-orcid":false,"given":"Hongzheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"},{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiante","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangrui","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"},{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-8692","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"},{"name":"Zhejiang Key Laboratory of Soft Matter Biomedical Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010024\u201000693\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000377\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100179\u20103"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001035\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2971"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl0372"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001660\u2010y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060858\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309719"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.135"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20240007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20220019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500432"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230047"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230024"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201061141\u20101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230029"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.07.032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010025\u201001374\u2010z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210679"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0496"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.136"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409898"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309966"},{"key":"e_1_2_9_28_1","first-page":"0445","article-title":"Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing","volume":"7","author":"Li H.","year":"2024","journal-title":"Research (Wash D C)"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3323"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.429"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20240056"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29713"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600844"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151138"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001178\u20106"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113269"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100894"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03504"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c17942"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162108"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102138"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300902"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202514483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202514483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202514483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:50:16Z","timestamp":1781524216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202514483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":42,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/smll.202514483"],"URL":"https:\/\/doi.org\/10.1002\/smll.202514483","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14483"}}