{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:06:02Z","timestamp":1784120762638,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378053"],"award-info":[{"award-number":["22378053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT22YG237"],"award-info":[{"award-number":["DUT22YG237"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Titanium\u2010based materials hold great biomedical potential owing to excellent biocompatibility. But titanium diboride (TiB\n                    <jats:sub>2<\/jats:sub>\n                    ), an emerging metal boride, is rarely explored for antitumor use, and developing multifunctional TiB\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based nanoplatforms with enhanced catalytic activity is urgently needed. Herein, we constructed a nanoplatform (TiB\n                    <jats:sub>2<\/jats:sub>\n                    \u2010PEG\u2010DOX) by modifying TiB\n                    <jats:sub>2<\/jats:sub>\n                    nanosheets (TiB\n                    <jats:sub>2<\/jats:sub>\n                    NSs) with amino polyethylene glycol (NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010PEG\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    ) and loading doxorubicin (DOX) via electrostatic interaction. We first clarified the boron (B)\u2010mediated Ti valence cycle: B regulates Ti electron transfer, promotes Ti\n                    <jats:sup>4+<\/jats:sup>\n                    reduction to Ti\n                    <jats:sup>2+<\/jats:sup>\n                    , enhancing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010rich tumor microenvironment Fenton\u2010like reaction to generate cytotoxic \u2022OH for chemodynamic therapy (CDT). Meanwhile, TiB\n                    <jats:sub>2<\/jats:sub>\n                    \u2010PEG\u2010DOX shows 53.53% photothermal conversion efficiency under 808\u00a0nm near\u2010infrared (NIR) irradiation for efficient photothermal therapy (PTT), and NIR further triggers on\u2010demand DOX release. DOX accumulates at tumor sites via the enhanced permeability and retention (EPR) effect to exert chemotherapy (CT). In vitro, it eliminates 86.32% of HCT\u2010116 colorectal cancer cells via CDT\/PTT\/CT synergy; in vivo, it achieves nearly complete tumor ablation in mice with excellent biocompatibility. This work provides a high\u2010performance synergistic antitumor platform and establishes a B\u2010modulated metal valence cycling paradigm, paving the way for titanium\u2010based nanomedicines.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514529","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:48:52Z","timestamp":1769860132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Harnessing Boron\u2010Mediated Ti Valence Cycling in TiB\n                    <sub>2<\/sub>\n                    \u2010PEG\u2010DOX: A Multimodal CDT\/PTT\/CT Platform for Colorectal Cancer Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Yueguang","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals and School of Chemical Engineering Dalian University of Technology 2 Linggong Road Dalian P. R. 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