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Failure to achieve appropriate management and closure can lead to serious consequences, such as cerebrospinal fluid (CSF) leakage and subsequent meningitis. Current grafts and synthetic patches often lack biological activity, mechanical integration, and sealing capacity. Here, we developed a multifunctional, injectable composite scaffold composed of collagen\/silk\u2010fibroin (S\u2010F) and \u03b1\u2010tricalcium phosphate (\u03b1\u2010TCP), designed for simultaneous CSF sealing and tissue regeneration. The upper S\u2010F\u2010rich layer forms a dense, non\u2010porous barrier to prevent CSF egress, while the lower \u03b1\u2010TCP\u2010containing layer promotes osteointegration and mechanical support. The scaffold is fabricated via a cryogelation\u2010inspired process, enabling shape\u2010memory behavior for minimally invasive deployment. In vitro studies confirmed favorable cell adhesion, matrix protein expression, and osteogenic activation. In vivo evaluation further indicated stable integration of the composite at the implantation site without severe adverse tissue responses. Overall, these results support the potential of this layered, shape\u2010memory composite as a dual\u2010functional platform for cranial base reconstruction.<\/jats:p>","DOI":"10.1002\/smll.202514794","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:14:23Z","timestamp":1775758463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shape\u2010Memory Collagen\/Silk\u2010Fibroin Scaffold for Dura Sealing and Skull Base Regeneration"],"prefix":"10.1002","volume":"22","author":[{"given":"SooJung","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Precision Medicine Sungkyunkwan University School of Medicine (SKKU\u2010SOM)  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine Sungkyunkwan University School of Medicine (SKKU\u2010SOM)  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeYoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine Sungkyunkwan University School of Medicine (SKKU\u2010SOM)  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Duk","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-2171","authenticated-orcid":false,"given":"GeunHyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine Sungkyunkwan University School of Medicine (SKKU\u2010SOM)  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-199406000-00006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040902"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.628129"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-915629"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111246"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0954411920926071"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2018.1550139"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2018.1480749"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.04.068"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42097-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2020.0231"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.906162"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000289713.80178.ce"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789814291064_0126"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae160"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202300359"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj0616"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.13004\/kjnt.2017.13.2.63"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.08.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm0345460"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.09.087"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.379"},{"key":"e_1_2_9_25_1","volume-title":"Physical Chemistry of Surfaces","author":"Adamson A. 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