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Here, we present SQ\u00a0905\u2010Gd, a small\u2010molecule squaraine\u2010based dual\u2010modality probe designed for NIR\u2010II and MRI imaging to address this need. This probe uniquely leverages an aggregation\u2010caused quenching (ACQ) effect and intrinsic liver\u2010targeting properties to enable a double\u2010reversal imaging strategy. Preoperatively, SQ\u00a0905\u2010Gd enhances\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted MRI, brightening liver tumors. Intraoperatively, the same aggregates quench NIR\u2010II fluorescence, darkening tumors against normal tissue and allowing clear visualization of sub\u20112\u00a0mm lesions. Additionally, fluorescence can be restored ex vivo by solvent extraction, enabling real\u2010time confirmation of complete resection. To our knowledge, this is the first small\u2010molecule dual\u2010modal probe that utilizes in vivo ACQ to achieve bright\/dark reversible contrast across both MRI and NIR\u2010II imaging, offering a powerful tool for precise liver cancer surgery.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514804","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:48:56Z","timestamp":1774514936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H\u2010Aggregated Squaraine Probe NIR\u2010II\/MRI Double Reversal Imaging for Liver Cancer Precise Surgical Navigation"],"prefix":"10.1002","volume":"22","author":[{"given":"Ruihu","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Biology Molecular Imaging Center Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  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