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Enhancing electron\u2010withdrawing capacity strengthens intramolecular charge transfer (ICT) in singlet excited states (S\n                    <jats:sub>n<\/jats:sub>\n                    ), enabling a direct charge transfer\u2010mediated intersystem crossing (ISC) pathway. Key parameters\u2014favorable singlet\u2010triplet gap (\u0394E &gt; 0, thermodynamic prerequisite), low reorganization energy (\u03bb, kinetic driver), and strong spin\u2010orbit coupling (SOC, ISC activator)\u2014optimize ISC efficiency, an exceptionally high S\n                    <jats:sub>1<\/jats:sub>\n                    \u2192T\n                    <jats:sub>1<\/jats:sub>\n                    ISC rate of 2.94 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    for DPCMQ. This high ISC efficiency populates the T\n                    <jats:sub>1<\/jats:sub>\n                    state, where DPCMQ benefits from optimal descriptors (lowest E\n                    <jats:sub>b<\/jats:sub>\n                    and \u03bb\n                    <jats:sub>T1<\/jats:sub>\n                    ) for efficient electron transfer. Its performance is further boosted in aggregates by restricted molecular motion and a hydration\u2010promoted microenvironment. This design selectively promotes hydroxyl radical (\u2022OH) generation over oxygen\u2010dependent superoxide pathways, while low triplet energy suppresses Type II activity. The framework provides a predictive blueprint for advanced photodynamic therapy optimized for hypoxic conditions.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514808","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T20:41:30Z","timestamp":1779655290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acceptor Engineering\u2010Mediated Charge\u2010Transfer Control: A Hierarchical Framework for Predictive Design of High\u2010Performance Type I AIE Photosensitizers"],"prefix":"10.1002","volume":"22","author":[{"given":"Jianfang","family":"Cao","sequence":"first","affiliation":[{"name":"School of Chemical Engineering, Ocean and Life Sciences Dalian University of Technology  Panjin China"},{"name":"State Key Laboratory of Fine Chemicals Dalian University of Technology  Dalian 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