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Hydrogels are ideal candidates for wound administration because of their high hydration, structural porosity, and extracellular matrix mimicking properties. Chitosan (CS) is the core matrix for building hydrogels because of its inherent biocompatibility, oxygen permeability, hemostatic, and antimicrobial activities. Through reversible cross\u2010linking strategies with dynamic covalent bonds (e.g., Schiff base and borate\u2010diol) and physical interactions (hydrogen bonding, electrostatic interactions, and host\u2010guest interactions, etc.), CS\u2010based hydrogels can dynamically adapt to the complex microenvironment of wounds. In recent years, researchers have developed smart CS hydrogel dressings with biocompatible and biodegradable, hemostatic\/adhesive, antimicrobial, antioxidant, anti\u2010inflammatory, stimulus\u2010responsive (pH\/temperature\/glucose), controlled\u2010release, and self\u2010healing functionalities in response to diverse needs during wound healing. In acute wounds, its rapid hemostatic and infection control properties significantly accelerate healing, while for chronic wounds (e.g., drug\u2010resistant bacteria\u2010infected wounds, deep burns, and diabetic ulcers), it breaks down healing barriers through synergistic mechanisms including photothermal, antimicrobial, macrophage polarization modulation, reactive oxygen species scavenging, and vascular regeneration promotion. This article contains a comprehensive review of the design principles, functional optimization, and the recent progress of CS\u2010based hydrogels for wound healing, as well as a further outlook on the future direction of hydrogel dressings in wound treatment.<\/jats:p>","DOI":"10.1002\/smll.202514813","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:17:51Z","timestamp":1770279471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Versatile Chitosan\u2010Based Hydrogel Dressings for Multi\u2010Scenario Wound Management"],"prefix":"10.1002","volume":"22","author":[{"given":"Ling","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University  Nanjing P. R. 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