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Disorders like nephrocalcinosis and calcium oxalate (CaOx) nephropathy cause inflammation and renal failure without effective therapy. To address this challenge, ultra\u2010small platinum\u2010selenium (Pt\u2010Se) nanoparticles (NPs) were synthesized to inhibit CaOxcrystallization by adsorbing C\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    to block nucleation and by binding to crystal growth sites. in vitro and in vivo studies were performed to assess the inhibition of CaOx crystallization and oxalate\u2010induced AKI. Pt\u2010Se NPs not only suppressed CaOx crystallization but also inhibited crystal\u2010cell interactions, thereby reducing CaOx\u2010induced cell damage. Furthermore, in a hyperoxaluria mouse model, these NPs significantly decreased renal CaOx crystal deposition and attenuated kidney injury with excellent biocompatibility. In conclusion, ultra\u2010small Pt\u2010Se NPs represent a promising therapeutic strategy for acute CaOx crystal\u2010induced nephropathy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514825","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:52:33Z","timestamp":1770483153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Therapeutic Effects of Ultra\u2010Small Platinum\u2010Selenium Nanoparticles on Oxalate\u2010Induced Acute Kidney Injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Nannan","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education)  Harbin 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