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Current therapies suffer from poor penetration and inadequate management of inflammation. To overcome these challenges, we developed a novel bioinspired nanoparticle. A VEGF\u2010inhibiting peptide was co\u2010assembled with Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    for stability and then modified with a reactive oxygen species (ROS) scavenger and a cell\u2010penetrating peptide. This multi\u2010functional design enables deep corneal penetration and targeted action. The resulting nanoparticle significantly prolongs ocular retention to 70 min. It achieved a remarkable penetration depth of 300\u00a0\u00b5m in a 3D corneal model, ensuring delivery to the site of disease. The nanoparticle demonstrated a dual mechanism of action; it effectively scavenged 60.31% of excess ROS and downregulated inflammation, reducing pro\u2010inflammatory macrophage polarization. This reshaped the immune microenvironment and potently suppressed angiogenesis, achieving 60.45% growth inhibition in the 3D model. In an animal model, the treatment successfully reduced abnormal blood vessel growth, with immunofluorescence confirming significantly lower expression of key inflammatory markers. This work presents a simple yet highly efficient strategy for deep ocular drug delivery, offering a potent therapeutic approach for CorNV and other oxidative stress\u2010 and inflammation\u2010related eye diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514865","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:54:46Z","timestamp":1774940086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinspired Anti\u2010VEGF Peptide Nanoparticle with Immune Regulating and Corneal Epithelium Penetration Capability for Corneal Neovascularization Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Polymeric Materials Tongji University of Materials Science and Engineering  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zhongshan Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Polymeric Materials Tongji University of Materials Science and Engineering  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Electronic and Information Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zhongshan Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-8331","authenticated-orcid":false,"given":"Min","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Polymeric Materials Tongji University of Materials Science and Engineering  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.07.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108457"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031981\u20102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000671\u2010z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21698"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2011.08.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10807683251370551"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671\u2010025\u201004234\u20106"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900610"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042374\u20104"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx0153"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado1749"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn7006"},{"key":"e_1_2_8_16_1","article-title":"Electrodeposited Superhydrophilic\u2010Superhydrophobic Composites for Untethered Multi\u2010Stimuli\u2010Responsive Soft Millirobots","volume":"35","author":"Dzuvor C. 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