{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:36:29Z","timestamp":1787322989668,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20539"],"award-info":[{"award-number":["U22A20539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515011763"],"award-info":[{"award-number":["2025A1515011763"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B17018"],"award-info":[{"award-number":["B17018"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inspired by cellular compartmentalization, porous microreactors provide confined microenvironments that enhance molecular collisions and mass transport, thereby enabling advanced catalysis, drug delivery, and bioengineering. However, fabricating reactors with hierarchical hydrophobic\u2013hydrophilic domains and tunable meso\u2010\/macroporosity remains challenging. Here, we report the scalable synthesis of zein mesoporous particles (ZMP) using an antisolvent precipitation method with inorganic salts as removable templates. The resulting ZMP exhibit tunable pore sizes (19\u2013302\u00a0nm) and a robust core\u2013shell structure, with hydrophobic \u03b1\u2010zein subunits localized in the core and hydrophilic subunits forming a porous outer shell. Dual\u2010dye fluorescence imaging and confocal microscopy confirm this amphiphilic architecture, while selective partitioning of hydrophobic and hydrophilic guest molecules further verifies the spatial heterogeneity. Enzymatic loading experiments demonstrate the potential of ZMP as active biocatalytic microreactors under mild conditions. These protein\u2010based porous materials provide a sustainable and biocompatible alternative to inorganic systems, offering a programmable platform for biomimetic catalysis, molecular separation, and green manufacturing.<\/jats:p>","DOI":"10.1002\/smll.202514892","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:04:41Z","timestamp":1781777081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Strategy to Fabricate Hierarchically Porous Zein Microreactors With a Hydrophobic Core\u2013Hydrophilic Shell Architecture"],"prefix":"10.1002","volume":"22","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Research and Development Centre of Food Proteins School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products Safety South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Like","family":"Wang","sequence":"additional","affiliation":[{"name":"Research and Development Centre of Food Proteins School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products Safety South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Research and Development Centre of Food Proteins School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products Safety South China University of Technology  Guangzhou P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Yang","sequence":"additional","affiliation":[{"name":"Research and Development Centre of Food Proteins School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products Safety South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-6316","authenticated-orcid":false,"given":"Shouwei","family":"Yin","sequence":"additional","affiliation":[{"name":"Research and Development Centre of Food Proteins School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products Safety South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010024\u201000658\u20103"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202005334"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.201701082"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b02556"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025226\u2010x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b03632"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat2816"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010020\u201000526\u20105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2019.08.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00432A"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00546"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010020\u20100161\u20108"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.09.202"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1149\/1.2408094"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703663"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.matsci.35.103103.120732"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041053\u20108"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav4302"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1172"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c02213"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2014.08.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0926\u20106690(00)00064\u20109"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/la204204j"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18103"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC06649D"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202420401"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207418"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1jm11163a"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1120251"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07424E"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0546424"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/la904549t"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201201321"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03286"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c01965"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c04501"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202514892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202514892","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202514892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:36:19Z","timestamp":1787319379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202514892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":36,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/smll.202514892"],"URL":"https:\/\/doi.org\/10.1002\/smll.202514892","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2025-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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