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Here, we report a biomimetic St\u00f6ber\u2010based encapsulation strategy that preserves the native chain architecture while imparting structural robustness and enhanced safety. The resulting B\u2010MNC exhibit a coercivity (33.6 mT), approximately 5\u00d7 higher than magnetosomes, 1.4\u00d7 higher than intact magnetotactic bacteria, and 2.2\u00d7 higher than chemically synthesized analogs (C\u2010MNC22). Magnetic characterization reveals ideally uniaxial single\u2010domain behavior with a remanence ratio (\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>rs<\/jats:sub>\n                    <jats:italic>\/M<\/jats:italic>\n                    <jats:sub>s<\/jats:sub>\n                    ) of 0.5, outperforming magnetosomes (0.35), bacteria (0.46), and C\u2010MNC22 (0.27). Under an alternating magnetic field (144.1\u00a0kHz, 34.7 kA m\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), aligned B\u2010MNC achieve a specific absorption rate (\n                    <jats:italic>SAR<\/jats:italic>\n                    ) of 1749.7\u00a0W g\n                    <jats:sup>\u22121<\/jats:sup>\n                    , which is approximately 4.72\u00d7 greater than purified magnetosomes, enabling rapid and efficient heating. In vitro, silica encapsulation markedly improves colloidal stability and cytocompatibility. Upon magnetic hyperthermia (42\u00b0C, 20\u00a0min), B\u2010MNC induce 71.4% death of MB49 bladder cancer cells versus only 12.4% for bare magnetosomes. This biomimetic assembly preserves the superior magnetic properties of native magnetosome chains while enhancing magnetic hyperthermia efficacy and biostability, establishing B\u2010MNC as a promising platform for safe and effective magnetic cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202514961","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:40:58Z","timestamp":1774802458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biomimetic Single\u2010Domain Magnetic Nanochains Surpassing Magnetotactic Bacteria in Hyperthermia Efficiency"],"prefix":"10.1002","volume":"22","author":[{"given":"Zan","family":"Gao","sequence":"first","affiliation":[{"name":"Institute of Advanced Synthesis (IAS) and School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Centre For Advanced Materials Nanjing Tech University  Nanjing P. R. 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