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Here, we report single Cu atom sites (1.42 wt.%) anchored on Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles (Cu\n                    <jats:sub>1<\/jats:sub>\n                    \u2010Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ) that dramatically enhance reactivity and molecular sensing properties of the support at low temperature. The Cu\n                    <jats:sub>1<\/jats:sub>\n                    are identified by x\u2010ray absorption near edge structure and feature metal\u2013support interaction between the atomically dispersed Cu (mostly in 2+ oxidation state) and Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    , as revealed by x\u2010ray photoelectron spectroscopy. The ability of Cu\n                    <jats:sub>1<\/jats:sub>\n                    to form interfacial Cu\u2013O\u2013Co linkages strongly reduces the temperature of lattice oxygen activation compared to CuO nanoparticles on Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    (CuO\n                    <jats:sub>NP<\/jats:sub>\n                    \u2010Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ), as demonstrated by temperature\u2010programmed reduction and desorption analyses, in agreement with density functional theory calculations. To demonstrate practical impact, we deploy Cu\n                    <jats:sub>1<\/jats:sub>\n                    \u2010Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles as a chemoresistive sensor for formaldehyde that yields more than an order of magnitude higher response than CuO\n                    <jats:sub>NP<\/jats:sub>\n                    \u2010Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    and consistently outperforms state\u2010of\u2010the\u2010art sensors. Formaldehyde is detected down to 5 parts\u2010per\u2010billion at 50% relative humidity and 75\u00b0C with excellent selectivity over critical interferents. These results establish a strategy for activating redox\u2010active supports using single\u2010atom isolates of non\u2010noble nature, yielding drastically enhanced and well\u2010defined reactivity to promote low\u2010temperature oxidation reactions and selective analyte sensing.\n                  <\/jats:p>","DOI":"10.1002\/smll.202600033","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:22:45Z","timestamp":1776064965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single Cu Atom Sites on Co\n                    <sub>3<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    Activate Interfacial Oxygen for Enhanced Reactivity and Selective Gas Sensing at Low Temperature"],"prefix":"10.1002","volume":"22","author":[{"given":"Hamin","family":"Shin","sequence":"first","affiliation":[{"name":"Human\u2010centered Sensing Laboratory Department of Mechanical and Process Engineering ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-1573","authenticated-orcid":false,"given":"Matteo","family":"D'Andria","sequence":"additional","affiliation":[{"name":"Human\u2010centered Sensing Laboratory Department of Mechanical and Process Engineering ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yin","sequence":"additional","affiliation":[{"name":"Green X\u2010Tech Center Green Goals Initiative Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Human\u2010centered Sensing Laboratory Department of Mechanical and Process Engineering ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Green X\u2010Tech Center Green Goals Initiative Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Chemical Engineering Hanyang University  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Krumeich","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences Laboratory of Inorganic Chemistry ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-752X","authenticated-orcid":false,"given":"Andreas T.","family":"G\u00fcntner","sequence":"additional","affiliation":[{"name":"Human\u2010centered Sensing 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