{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:04:57Z","timestamp":1789380297031,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00MH120279"],"award-info":[{"award-number":["R00MH120279"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS144777"],"award-info":[{"award-number":["R21NS144777"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31NS151910"],"award-info":[{"award-number":["F31NS151910"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ocular hypertension is commonly linked with glaucomatous neurodegeneration. To investigate the mechanisms of glaucoma,\n                    <jats:italic>in vivo<\/jats:italic>\n                    models typically induce intraocular pressure elevation by obstructing aqueous humor flow in the trabecular meshwork. However, there is no satisfying\n                    <jats:italic>in vivo<\/jats:italic>\n                    model to maintain stable ocular hypertension and replicate neurodegenerative features accurately. Here, we introduce an injectable oil microdroplet model that achieves sustained IOP elevation and a 44.3% loss of retinal ganglion cells within four weeks in mice. The oil microdroplets exhibit an underwater \u201csuperoleophobic\u201d state with high adhesion forces upon contact with tissue. Upon intracameral injection, the oil microdroplets deform and retain within various\u2010sized trabecular architectures via a \u201cself\u2010locking\u201d mechanism driven by differential Laplace pressures. Applying this oil microdroplet\u2010induced mouse model, we observed an increase in nocturnal sleepiness, reflecting the increased daytime sleepiness observed in human glaucoma patients. This injectable oil microdroplet model provides a platform for studying glaucoma progression and evaluating potential therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1002\/smll.202600069","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:24:32Z","timestamp":1789377872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Adhesion Superoleophobic Oil Microdroplets to Create Ocular Hypertension\n                    <i>In Vivo<\/i>"],"prefix":"10.1002","author":[{"given":"Eunji","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorcas","family":"Matuwana","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwen","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruobai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geunho","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolle","family":"Gudiel Winter","sequence":"additional","affiliation":[{"name":"Commonwealth Honors College University of Massachusetts  Amherst Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"},{"name":"Integrative Neuroscience Program Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-6732","authenticated-orcid":false,"given":"Qianbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Binghamton University, State University of New York  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"126","article-title":"Chronic Experimental Glaucoma in Primates. 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