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To address this challenge, we developed a smart pH\u2010responsive hyaluronic acid microneedle patch (CV MN) loaded with vancomycin and cerium\u2010based Prussian blue analogs (CPB) for time\u2010coordinated therapy of MRSA\u2010infected wounds. This system realizes its function by using the dynamic pH changes during wound healing: in the acidic infectious microenvironment, vancomycin is rapidly released to exert powerful bactericidal effects, and the release of cerium ions from CPB is accelerated to scavenge reactive oxygen species (ROS) via its catalase (CAT) and superoxide dismutase (SOD) activities. When the pH becomes neutral during the repair phase, the continuously released cerium ions sustainably modulate the immune microenvironment. In vitro experiments demonstrated that CV MN exhibited excellent antibacterial activity and biofilm disruption efficacy against MRSA. CPB had potent ROS\u2010scavenging capacity, protected mitochondrial function, and promoted fibroblast migration, angiogenesis, and macrophage polarization toward the pro\u2010healing M2 macrophage phenotype. In mouse full\u2010thickness infected wound\/abscess models, CV MN accelerated wound healing, reduced bacterial burden, attenuated inflammation, and reshaped immunity via an anti\u2010inflammatory program, providing a novel synergistic strategy for chronic infected wounds.<\/jats:p>","DOI":"10.1002\/smll.73536","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T16:34:16Z","timestamp":1777221256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["pH\u2010Adaptive Microneedle Patch Based on Cerium\u2010Based Prussian Blue Analogues for the Treatment of MRSA\u2010Associated Wound Infections"],"prefix":"10.1002","volume":"22","author":[{"given":"Jun","family":"Liang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Anhui Medical University  Hefei Anhui P. R. 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