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Wearable transdermal drug delivery offers a promising treatment with high bioavailability and sustained drug concentrations. However, current technologies struggle with issues such as high cost, low comfort, risk of infection, or tissue pain and damage. Here, we present a breathable, stretchable electroporation patch (BSEP) that seamlessly integrates the traditional drug patch with electroporation\u2010enhanced transdermal drug delivery technology in a low\u2010cost manner. Conductive ink was patterned and deposited onto a breathable and stretchable non\u2010woven fabric substrate using screen printing. A unique serpentine interdigitated design for stretchable electrodes was adopted to precisely localize the electric field within the superficial layers of the skin, reducing voltage in deep tissues by &gt;50% and minimizing potential damage. Cytotoxicity tests and histological analyses confirmed the biocompatibility and safety of the materials and device. Finally, animal experiments validated the effectiveness of the BSEP in enhancing drug delivery, achieving a two\u2013threefold increase in skin penetration compared to the control group. These findings collectively suggest that the developed BSEP holds significant promise for transdermal drug delivery applications.<\/jats:p>","DOI":"10.1002\/smll.73624","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:58Z","timestamp":1777842358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breathable, Stretchable Electroporation Patches for Drug Delivery"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhuoran","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences  Beijing China"},{"name":"College of Mechanical Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Guo","sequence":"additional","affiliation":[{"name":"Human Organ Physiopathology Emulation System Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology  Beijing China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences  Beijing China"},{"name":"School of Engineering Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkai","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences  Beijing China"},{"name":"School of Engineering Science University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Medical Polymer Materials Technology and Application Tuoren Medical Device Research &amp; Development Institute Co., Ltd. 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