{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:24:09Z","timestamp":1783013049159,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073380"],"award-info":[{"award-number":["82073380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["(Interdisciplinary Program"],"award-info":[{"award-number":["(Interdisciplinary Program"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["Grant No. YG2022ZD011)"],"award-info":[{"award-number":["Grant No. YG2022ZD011)"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Current nanotheranostics are plagued by non\u2010target drug release and uncontrolled activation which compromise imaging fidelity and therapeutic precision. Herein, we report an origin\u2010regenerated Cu\n                    <jats:sub>9<\/jats:sub>\n                    S\n                    <jats:sub>8<\/jats:sub>\n                    @CH1055@Cu\n                    <jats:sub>9<\/jats:sub>\n                    S\n                    <jats:sub>8<\/jats:sub>\n                    nanocapsules (CCC NCs) that unlocks dual\u2010modal imaging\u2010guided trimodal therapy via a light\u2010triggered \u201clid\u2010off\u201d mechanism. The dense outer Cu\n                    <jats:sub>9<\/jats:sub>\n                    S\n                    <jats:sub>8<\/jats:sub>\n                    shell tightly encapsulates the NIR\u2010II dye CH1055, ensuring its dormant state during systemic circulation. Upon the 1064 nm laser irradiation, localized surface plasmon resonance (LSPR) induces rapid photothermal disruption of the lid, thereby achieving a light\u2010gated \u201clid\u2010off\u201d effect. This effect synchronously enables high\u2010contrast NIR\u2010II fluorescence\/photoacoustic dual\u2010modal imaging and initiates on\u2010demand trimodal therapy integrating photothermal ablation, chemodynamic therapy, and cuproptosis. The single near infrared wavelength\u2010triggered design achieves remarkable suppression of Mouse prostate carcinoma (RM\u20101) prostate tumor progression with no detectable systemic toxicity. Thereby, our work establishes the \u201clid\u2010off\u201d nanoarchitecture as a robust platform for spatiotemporally precise, imaging\u2010guided multimodal cancer theranostics.\n                  <\/jats:p>","DOI":"10.1002\/smll.73776","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:43:08Z","timestamp":1778751788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Plasmonic \u201cLid\u2010Off\u201d Nanoplatform for Spatiotemporally Controlled PA\/NIR\u2010II Dual\u2010Modal Imaging and Cuproptosis\u2010Based Synergistic Photothermal and Chemodynamic Therapy"],"prefix":"10.1002","volume":"22","author":[{"given":"Yingao","family":"Jiao","sequence":"first","affiliation":[{"name":"Institute of Intelligent Health Diagnosis and Treatment School of Automation and Intelligent Sensing Shanghai Jiao Tong University  Shanghai P. R. 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