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Here, one\u2010pot solvothermal synthesis of Mn, Yb, and Er co\u2010doped BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    (FMBTO) is reported, a first\u2010in\u2010class NIR\u2010II fluorescence\u2010emitting piezoelectric nanocomposite that integrates imaging, catalytic therapy, and innate immune activation within a single framework. Yb\n                    <jats:sup>3+<\/jats:sup>\n                    \/Er\n                    <jats:sup>3+<\/jats:sup>\n                    doping imparts intrinsic NIR\u2010II fluorescence, eliminating the need for external fluorophores or downconversion nanoparticles, while Mn\n                    <jats:sup>2+<\/jats:sup>\n                    incorporation enables piezoelectric enhancement, T1\u2010weighted MRI contrast, Fenton\u2010like chemodynamic catalysis, and potent cGAS\u2010STING immune activation. Defect engineering within the BTO lattice significantly enhances piezocatalytic reactive oxygen species (ROS) generation, even under severe hypoxia, and simultaneously promotes Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition to liberate molecular oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ), thereby reversing hypoxia and downregulating HIF\u20101\u03b1. In an orthotopic liver tumor model, FMBTO demonstrates strong tumor accumulation, NIR\u2010II\/MRI\u2010guided treatment precision, and ultrasound (US)\u2010triggered PZDT\u2010CDT synergy, leading to extensive tumor apoptosis, immune\u2010cell recruitment, and robust STING pathway activation. Collectively, FMBTO establishes a versatile nanotheranostic paradigm that couples deep\u2010tissue imaging with oxygen\u2010independent ROS production and innate immune stimulation, offering a powerful strategy for treating hypoxic and immunosuppressed solid tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.73808","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:31:56Z","timestamp":1778837516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["NIR\u2010II Fluorescent Nanoplatforms with Defect\u2010Regulated Piezoelectricity for Dual NIR\u2010II\/MRI\u2010Guided, Hypoxia\u2010Resilient Piezo\u2010Chemodynamic Therapy and cGAS\u2010STING Activation in Orthotopic Liver Tumor"],"prefix":"10.1002","volume":"22","author":[{"given":"Shubham","family":"Roy","sequence":"first","affiliation":[{"name":"School of Science Harbin Institute of Technology  Shenzhen Guangdong 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