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Conventional treatments, including pharmacological agents, biologics, and fecal microbiota transplantation, are limited by adverse effects, immune suppression, recurrence, and low patient acceptance. In this study, food\u2010derived probiotic extracellular vesicles (EVs) from\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    with dietary polysaccharide (chitosan) and polyphenol (tannic acid) are developed as a synergistic therapeutic strategy for inflammatory bowel disease. The engineered biohybrid with dual\u2010functional coating confers gastrointestinal stability and colon\u2010targeted delivery, while scavenging reactive oxygen species and preserving the intrinsic microbiota\u2010regulating properties of probiotic EVs. Multi\u2010omics approach reveals correlations among microbial community shifts, short\u2010chain fatty acids, oxidative stress modulation, inflammatory cytokine profiles, and disease severity indices. This work provides a promising approach and reveals the synergistic mechanisms of engineered probiotic EVs in reshaping gut microbiota, modulating metabolic networks, and improving the inflammatory microenvironment for the treatment of inflammatory bowel disease.\n                  <\/jats:p>","DOI":"10.1002\/smll.73858","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:16:09Z","timestamp":1779290169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Food\u2010Derived Biohybrid Probiotic Extracellular Vesicles for Synergistic Therapy of Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Mengliu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"College of Biosystems Engineering and Food Science Zhejiang Key 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