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However, its efficacy is severely limited by tumor microenvironment (TME) features such as hypoxia and elevated antioxidant levels (e.g., glutathione, GSH). To address these challenges, a GSH\u2010responsive nanoplatform (enBDP\u2010F NPs) was developed by integrating a heavy\u2010atom\u2010free photosensitizer (enBDP) with perfluorooctanoic acid (PFOA). The donor\u2013acceptor\u2010structured enBDP, featuring an anthracene\u2010modified BODIPY core, enables efficient ROS generation via a spin\u2013orbit charge transfer intersystem crossing (SOCT\u2010ISC) mechanism. In the TME, enBDP\u2010F NPs undergo GSH\u2010triggered disassembly, releasing PFOA to alleviate hypoxia while simultaneously depleting intracellular GSH through disulfide bond cleavage, thereby disrupting redox homeostasis and suppressing ROS scavenging. This dual\u2010responsive mechanism synergistically enhances oxidative stress and promotes tumor cell death. Both in vitro and in vivo studies demonstrate that enBDP\u2010F NPs exhibit minimal dark toxicity but potent phototoxicity, significantly suppress tumor growth, reduce 4T1 cell viability to below 20% under irradiation, and display an oxygen\u2010carrying capacity approximately threefold higher than PBS. This work provides a promising strategy for synergistic TME modulation to enhance PDT efficacy in cancer therapy.<\/jats:p>","DOI":"10.1002\/smll.73860","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:35:41Z","timestamp":1779791741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Anthracenyl\u2010Functionalized Boron Dipyrromethene Based Glutathione\u2010Responsive Nanoplatform for Efficient Photodynamic Therapy Enhanced by Perfluorooctanoic Acid"],"prefix":"10.1002","author":[{"given":"Xingcan","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunya","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; Hubei Key Laboratory of Catalysis and Materials Science &amp; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science South\u2010Central Minzu University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"He","sequence":"additional","affiliation":[{"name":"National R&amp;D Center for Se\u2010Rich Agricultural Products Processing Hubei Engineering Research Center for Deep Processing of Green Se\u2010Rich Agricultural Products School of Modern Industry For Selenium Science and Engineering Wuhan Polytechnic University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanying","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education &amp; 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