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Specifically, these include rapid oxidative degradation in physiological environments and potential cytotoxicity derived from their metallic nature. To address these challenges, we develop a core\u2010shell structured nanikohybrid (CI@MXene) through the integration of natural cuttlefish ink melanin (CI) with MXene nanosheets. This biomimetic design establishes a protective barrier that effectively prevents MXene oxidation, thereby preserving its structural integrity and granting it durable antibacterial activity with sustained efficacy even after prolonged storage. Furthermore, the composite enables a mild photothermal therapy (PTT) under near\u2010infrared irradiation, maintaining skin temperature below 45\u00b0C. This gentle thermal effect synergizes with the preserved nano\u2010knife capability of the encapsulated MXene, resulting in remarkable eradication rates exceeding 95% against both\n                    <jats:italic>E. coil<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , along with approximately 80% disruption of established biofilms. More importantly, in vivo evaluation using a murine wound infection model demonstrated accelerated wound closure, significantly reduced bacterial burden, and attenuated inflammatory responses, accompanied by enhanced tissue regeneration. This work not only provides fundamental insights into the rational design of stable and biosafe MXene\u2010based nanomaterials but also establishes a novel strategy for synergistic physical antibacterial therapy, offering a promising approach for combating biofilm\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/smll.73934","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:45:43Z","timestamp":1779687943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuttlefish Ink\u2010Derived Melanin\/MXene Composites: Boosting Stability and Unleashing Synergistic Photothermal\u2010Mechanical Antimicrobial Effects Against Biofilms"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhenxing","family":"Tan","sequence":"first","affiliation":[{"name":"School of biomedical and pharmaceutical sciences Guangdong University of Technology  Guangzhou P. R. 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