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Here, we report a dynamic chemical modification strategy based on biorefinery\u2010derived hyperbranched nanoconfinement to fabricate a switchable adhesive for biomedical applications. Microbial fermentation produces hyperbranched biorefinery molecules with nanostructures that address common biomass\u2010related issues like long production cycles, unstable batches, and by\u2010product generation, while also providing abundant binding sites for high\u2010density dynamic bonds. This hyperbranched nanoconfinement enables substantial energy dissipation, facilitating efficient stress redistribution and interfacial reconfiguration at fracture sites, thereby achieving simultaneously excellent adhesive strength and switchable adhesion. The resulting switchable wound bioadhesive exhibits a wide switching span (296 to 17 N\/m) and high stability, enabling non\u2010invasive repair with a 94.80% wound closure rate after 10 days, significantly higher than the control (76.07%). This work explores the application of biorefinery molecules in the field of bio\u2010based adhesives and develops a promising candidate for innovating adhesion solutions in the biomedical field.<\/jats:p>","DOI":"10.1002\/smll.73951","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T14:51:36Z","timestamp":1779720696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbranched Biorefinery Molecule\u2010Regulated Switchable Adhesion and Noninvasive Healing"],"prefix":"10.1002","volume":"22","author":[{"given":"Kaiwen","family":"He","sequence":"first","affiliation":[{"name":"College of Biomass Science and Engineering Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Biomass Science and Engineering Sichuan University  Chengdu P. R. 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