{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:08:05Z","timestamp":1784887685251,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute lung injury (ALI) is a life\u2010threatening inflammatory syndrome closely associated with reactive oxygen species (ROS) burst and dysregulation of M1\/M2 macrophage polarization. Therefore, immune regulation of pulmonary macrophages represents a potential strategy to alleviate lung damage. However, existing approaches suffer from imprecise cellular targeting, monofunctional therapeutic effects, and suboptimal biocompatibility. To address these issues, an inhalable, multifunctional biomimetic nanoplatform is proposed that mimics apoptotic bodies (CTM@PS\u2010Lip). CTM@PS\u2010Lip is synthesized by fabricating nanoscale liposomes based on the outer leaflet structure of apoptotic cell membranes and encapsulating ROS responsive carbon dots (CDs)\u2010methylprednisolone (MP) conjugates. Upon inhalation, liposomes rich in phosphatidylserine (PS) can transmit the \u201ceat me\u201d signal, efficiently inducing macrophages to recognize and phagocytose. Subsequently, the high ROS microenvironment in ALI\u2010affected lung tissues triggers the controlled cargo release for: not only promoting the MP\u2010mediated immunomodulatory effects by inhibiting M1 macrophage polarization and inducing M2 macrophage polarization but also synergizing with the potent CDs mediated ROS\u2010scavenging capacity, significantly reducing pulmonary inflammation and promoting tissue repair. Thus, CTM@PS\u2010Lip integrates imaging, therapy, and biosafety, proving to be a promising strategy for safe and efficient management in ALI.<\/jats:p>","DOI":"10.1002\/smll.74008","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:00:19Z","timestamp":1780066819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Inhalable Apoptosis\u2010Mimicking Functionalized Carbon Dots\u2010Methylprednisolone Nanomedicine for Synergistic Therapy in Acute Lung Injury"],"prefix":"10.1002","volume":"22","author":[{"given":"Xin","family":"Pang","sequence":"first","affiliation":[{"name":"Key Laboratory for Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing University Chongqing University Fuling Hospital Chongqing University Cancer Hospital.  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Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing University Chongqing University Fuling Hospital Chongqing University Cancer Hospital.  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing University Chongqing University Fuling Hospital Chongqing University Cancer Hospital.  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