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Herein, a\n                    <jats:italic>Bifidobacterium breve<\/jats:italic>\n                    lw01\u2010based bioreactor (lw01@Pd) was engineered to facilitate the intracellular in situ biosynthesis of palladium nanocrystals (Pd NCs) via carbon monoxide (CO) reduction to alleviate the immunosuppression of cold tumors. The intrinsic hypoxic targeting capability of lw01 in solid tumors enables the selective tumor colonization of lw01@Pd and synchronously minimizes off\u2010target effects. Once within the tumor microenvironment (TME), the engineered lw01@Pd release Pd NCs via Xenophagy\u2010mediated degradation within tumor cells, which then induce oxidative damage to both tumor cells and lw01 carrier. This oxidative stress not only induces the immunogenic cell death (ICD) of tumor cells, but also triggers the lysis of lw01, resulting in the release of damage\u2010associated molecular patterns (DAMPs) and pathogen\u2010associated molecular patterns (PAMPs). The concurrent presence of DAMPs and PAMPs promotes the maturation of dendritic cells (DCs) and facilitates antigen presentation, which in turn activates CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells\u2013mediated adaptive immune response. This probiotic nano\u2010catalytic system demonstrates significant immunotherapeutic potential, offering new perspectives on overcoming the immune tolerance of cold tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.74027","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:06:24Z","timestamp":1780571184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Biosynthesis of Pd Nanocrystals in\n                    <i>Bifidobacterium<\/i>\n                    Bioreactor as Dual Immune Stimulators for Immuno\u2010Chemodynamic Therapy of Cold Tumor"],"prefix":"10.1002","volume":"22","author":[{"given":"Fangming","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites College of Life Science and Technology Beijing University of Chemical Technology  Beijing P. R. 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