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The oleic acid\u2010modified CoFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    (OA@CF) and carboxyl\u2010modified T cell\u2010targeting aptamers are selectively assembled onto the hydrophobic and hydrophilic domains of JSPs, respectively, which form an orthogonal surface structure capable of adhering on the cell membrane. The magnetic module enables the MVR to achieve membrane disruption, antigen release, capture, and magnetically guided delivery toward CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010enriched invasive tumor margins. The aptamer module allows MVR to act as APC\u2010T cell engagers to enhance CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010APC interactions and antigen presentation, triggering a feedforward loop that activates CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and promotes IFN\u2010\u03b3\u2010dependent differentiation of myeloid cells into MHC\u2010II\n                    <jats:sup>+<\/jats:sup>\n                    APCs and iNOS\n                    <jats:sup>+<\/jats:sup>\n                    effector cells. Both in vitro and in vivo results demonstrate that MVRs elicit spatially organized, multi\u2010effector immune response and suppress both primary and distal tumors. This work presents a distinctive and modular vaccine strategy for spatiotemporal orchestration of the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010myeloid cell immune loop, improving local immune activation and establishing a self\u2010amplifying antitumor immune response.\n                  <\/jats:p>","DOI":"10.1002\/smll.74059","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:48:57Z","timestamp":1780393737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modular Vaccine Robots for Spatiotemporal Programming of the CD4\n                    <sup>+<\/sup>\n                    T Cell\u2013Myeloid Cell Axis"],"prefix":"10.1002","volume":"22","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun Jilin P. 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