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Herein, we report on the development of an ultrafast, real\u2010time molecular diagnostic platform based on gallium\u2010based LM nanoparticles (LM NPs) grafted with programmable DNA\/polyacrylamide networks. LM NPs with strong and broadband plasmonic light absorption are demonstrated as efficient photothermal agents to enable stable temperature cycles, and the LM surface\u2010initiated polymerization reaction allows direct grafting of DNA\/polyacrylamide copolymer networks onto LM NPs, yielding core\u2013shell nanocomposites with significantly enhanced photothermal stability and capable of participating in enzymatic amplification reactions. Thanks to the efficient cascading of the photothermal process and the PCR\u2010based amplification process, real\u2010time detection of nucleic acid targets within 6.5\u00a0min is achieved, and the testing of different viral and bacterial targets with high sensitivity and specificity is achieved. The broadband light absorption of LM NPs also allows the molecular diagnostic platform works under portable LED devices, such as a LED flashlight, which can be further developed into low\u2010cost, rapid POCT molecular diagnostic devices for practical disease diagnosis and other applications.<\/jats:p>","DOI":"10.1002\/smll.74092","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:47:39Z","timestamp":1781272059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Programmable DNA\/Polyacrylamide Network\u2010Grafted Broadband Plasmonic Liquid Metal Nanoparticles for Ultrafast Real\u2010Time Molecular Diagnostics"],"prefix":"10.1002","volume":"22","author":[{"given":"Qingyu","family":"Gu","sequence":"first","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Nankai University  Tianjin P. 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