{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:02:24Z","timestamp":1785240144973,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202724"],"award-info":[{"award-number":["82202724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024MD754037"],"award-info":[{"award-number":["2024MD754037"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tophi, inflammatory granulomas formed by intra\u2010articular monosodium urate (MSU) crystal deposition, remain challenging due to limited drug efficacy. While arthroscopic surgery removes tophi rapidly, mechanical debridement risks injury, and intraoperative MSU release can trigger severe oxidative stress induced inflammatory storm. To overcome this, we developed a cascade nanozyme, Ce\u2010MOF@Pt, enabling synergistic MSU clearance and ROS scavenging for MSU\u2010induced gouty arthritis. Pt nanoparticles possess oxidase (OXD)\u2010like activity, dissolving deeply embedded MSU crystals without mechanical injury and incidentally producing anti\u2010inflammatory allantoin. The Ce\u2010MOF matrix supports Pt and duplicates catalase (CAT)\/superoxide dismutase (SOD)\u2010like activities, cascading H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition and MSU\u2010induced ROS elimination. As UA degradation elevates the local pH values, its dominant activity intelligently switches\u00a0from OXD\u2010like to SOD\u2010like mode, while the CAT\u2010like activity remains consistently high, ensuring continuous clearance of the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    byproduct and offering integrated anti\u2010oxidative therapy. In vitro, Ce\u2010MOF@Pt reduced inflammation via ROS scavenging and macrophage reprogramming. In vivo, it alleviated pain symptoms and joint inflammation in MSU\u2010induced gouty arthritis mice. Transcriptomics revealed Ce\u2010MOF@Pt mitigated the inflammatory storm by alleviating endoplasmic reticulum stress. This novel Ce\u2010MOF@Pt strategy offers minimally invasive tophi dissolution and prevents MSU\u2010induced inflammation, providing a promising therapeutic approach for tophi.\n                  <\/jats:p>","DOI":"10.1002\/smll.74140","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:02:39Z","timestamp":1781506959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cascade Nanozyme\u2010Catalyzed Tophi Dissolution and ROS Scavenging for Anti\u2010Inflammatory Therapy in Gouty Arthritis"],"prefix":"10.1002","volume":"22","author":[{"given":"Yi","family":"He","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission The First Affiliated Hospital of Chongqing Medical University  Chongqing P. R. 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