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However, insufficient tissue penetration of light largely limits the in vivo applications of photoresponsive therapeutics. With the aim to circumvent this limitation and to work within tissue depths that are pragmatically accessible to light, we developed an injectable and photodegradable hydrogel that could enable controlled drug delivery in subcutaneous tissue. In this work, we describe a hydrogel formulation consisting of a 2\u2010arm photocage bearing azide and a BCN\u2010terminated 4\u2010arm PEG. Gelation takes place in minutes upon mixing the two components via strain\u2010promoted azide\u2010alkyne cycloaddition (SPAAC). Both gel precursors are made water\u2010soluble and exhibit low viscosity prior to complete gelation, and the pre\u2010gel is easily injectable through 23G needles. Photocage photocleavage and consequent gel degradation could be precisely controlled with green light irradiation. We further showed that nanoparticles can be successfully encapsulated into the gel and subsequently photo\u2010released. The full operation process was demonstrated in an ex vivo porcine model and the acute biocompatibility of gel injection and degradation was evaluated in healthy human skin cultured ex vivo.<\/jats:p>","DOI":"10.1002\/smll.74162","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:29:07Z","timestamp":1782923347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BODIPY Photocage\u2010Based Injectable Hydrogel for Light\u2010Controlled Nanoparticle Release"],"prefix":"10.1002","volume":"22","author":[{"given":"Baihao","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics Department of Engineering Science and Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"},{"name":"Department of Materials Department of Bioengineering Institute of Biomedical Engineering Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Peeler","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics Department of Engineering Science and Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"},{"name":"Department of Materials Department of Bioengineering Institute of Biomedical Engineering Imperial College London  London UK"},{"name":"Department of Infectious Disease Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. 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