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The conventional treatments, including artificial tears and hydrogel\/contact\u2010lens approaches, all fail to achieve sustained friction control due to limited lubrication durability, rapid clearance, surface dehydration, and foreign\u2010body sensation. Here we developed a light\u2010triggered hydration\u2010lubricating nanoplatform (PAM@HK) that simultaneously restored ocular surface lubrication and enabled on\u2010demand anti\u2010inflammatory therapy. PAM@HK was assembled from an amphiphilic block copolymer that integrated a phosphorylcholine segment to form a robust hydration layer for hydration lubrication and an azobenzene hydrophobic segment for light\u2010switchable honokiol (HK) release. The tribological tests under blink\u2010relevant load and shear revealed that PAM achieved ultralow friction across macroscopic and microscopic scales, evidencing stable hydration lubrication. The near\u2010infrared light irradiation triggered reversible photo\u2010isomerization to greatly accelerate HK release on demand. In DED mouse model, PAM@HK markedly restored corneal integrity and tear film stability, increased tear secretion, preserved conjunctival goblet cells, and suppressed interleukin\u20106, reactive oxygen species, and pathological keratinization. This work positioned hydration lubrication as a primary therapeutic approach for DED and provided a new low\u2010invasive, light\u2010programmable strategy with superior durability and mechanistic relevance over conventional passive lubrication intervention.<\/jats:p>","DOI":"10.1002\/smll.74249","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:16:55Z","timestamp":1781777815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rebuilding Ocular Surface Lubrication with a Light\u2010Triggered Hydration\u2010Lubricating Nanoplatform for Dry Eye Disease Therapy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4373-5811","authenticated-orcid":false,"given":"Yinuo","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical Engineering Tsinghua University  Beijing 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