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To simultaneously target these interconnected pathological processes, we designed an organic\u2010inorganic hybrid, Res\u2010MnMo\n                    <jats:sub>6<\/jats:sub>\n                    , by covalently grafting a resveratrol\u2010derived ligand onto an Anderson\u2010type polyoxometalate (POM) cluster. Res\u2010MnMo\n                    <jats:sub>6<\/jats:sub>\n                    confers potent dual functionality, achieving 93% disassembly of preformed PrP106\u2010126 aggregates and effectively alleviating associated cytotoxicity and oxidative damage. Unlike conventional sacrificial antioxidants, the covalent integration fundamentally redirects the reactive oxygen species (ROS)\u2010scavenging mechanism toward a catalytic redox pathway, enabling sustained antioxidant activity. Notably, the ligand\u2010induced electronic redistribution within the POM scaffold enhances the catalytic efficiency by lowering the kinetic barriers of the rate\u2011determining steps in both superoxide (\u00b7O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and hydroxyl radical (\u00b7OH) scavenging reactions, leading to a long\u2010lasting catalytic ROS\u2011elimination performance.\n                  <\/jats:p>","DOI":"10.1002\/smll.74275","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:24:53Z","timestamp":1781778293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Covalent Resveratrol\u2010Polyoxometalate Hybrid for Synergistic Disassembly of Prion Protein Fragment 106\u2013126 Aggregates and Catalytic Scavenging of Reactive Oxygen 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