{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:32:11Z","timestamp":1787085131797,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["352900"],"award-info":[{"award-number":["352900"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atom\u2010precise metal nanoclusters (NCs) have garnered considerable attention due to their photoluminescence and catalytic properties arising from the quantum confinement effect and metal\u2010ligand interaction. However, the tendency of NCs to aggregate under reaction conditions hinders their catalytic activity. Surface\u2010protecting ligands can enhance the stability, but they often reduce surface exposure and, consequently, catalytic activity. The incorporation of surface\u2010cleaned clusters into the pores of metal\u2013organic framework (MOF) is highly desirable. Here, we constructed a hybrid structure in which Zr\u2010based MOF, UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , is grown directly on the surface of the [Au\n                    <jats:sub>9<\/jats:sub>\n                    (PPh\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>8<\/jats:sub>\n                    ](NO\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>3<\/jats:sub>\n                    cluster. During the nanocluster\u2010templated growth of MOF, the triphenylphosphine ligand was removed, yielding a surface\u2010clean gold cluster\u2010MOF composite material. An integrated experimental\u2010theoretical analysis revealed that the ligand\u2010free Au clusters occupy the pores of the MOF framework. This composite exhibited an overpotential of 65\u00a0mV and demonstrated a high chronopotentiometric stability in the hydrogen evolution reaction (HER). For the horseradish peroxidase (HRP)\u2010mimicking reaction, the Michaelis\u2013Menten constants (K\n                    <jats:sub>m<\/jats:sub>\n                    ) for H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and TMB were determined to be 0.1 and 2.7\u00a0m\n                    <jats:sc>m<\/jats:sc>\n                    , respectively. Experimental and computational studies demonstrated that the MOF\u2010induced confinement, coupled with NH\n                    <jats:sub>2<\/jats:sub>\n                    group interactions within its pores, modulates catalyst\u2013substrate interactions, thereby improving the catalytic performance and stability of the composite.\n                  <\/jats:p>","DOI":"10.1002\/smll.74276","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:09:17Z","timestamp":1782238157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stabilization of Ligand\u2010Free Small Gold Nanocluster Within a Metal\u2013Organic Framework for Enhanced Hydrogen Evolution and Horseradish Peroxidase\u2010Mimicking Catalysis in Aqueous Media"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5979-3382","authenticated-orcid":false,"given":"Glory","family":"James","sequence":"first","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravari Kandy","family":"Aparna","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dhananjay","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Electrochemical Process Engineering (EPE) Division CSIR\u2010Central Electrochemical Research Institute (CECRI)  Karaikudi Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udupa Sujit","family":"Manjunatha","sequence":"additional","affiliation":[{"name":"Materials Research Centre Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona Shaju","family":"Rose","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nonappa","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Natural Sciences Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-8078","authenticated-orcid":false,"given":"Seiji","family":"Yamazoe","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Tokyo Metropolitan University  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Kikkawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Tokyo Metropolitan University  Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Chathakudath","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"CSIR National Chemical Laboratory (NCL)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravishankar","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Materials Research Centre Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-0299","authenticated-orcid":false,"given":"Subrata","family":"Kundu","sequence":"additional","affiliation":[{"name":"Electrochemical Process Engineering (EPE) Division CSIR\u2010Central Electrochemical Research Institute (CECRI)  Karaikudi Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarak","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Delhi  Hauz Khas New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-8418","authenticated-orcid":false,"given":"Sukhendu","family":"Mandal","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00703"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00495"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412768"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07083"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae252"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202401443"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103206"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215364"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c04336"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR05460D"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00378"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13635"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.1c00009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00724D"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.11.023"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09136"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200700534"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093916"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/prechem.3c00008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801001105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14020310"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300014x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.9b09164"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsaem.5c03119"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialsau.3c00067"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2024.159475"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b07732"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cp52497c"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c09369"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201701519"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405063"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SU00199D"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2023.121755"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401926"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201020035\u20104"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/chin.200524023"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20100728(93)03043\u2010O"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20539d"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00219"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00475"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11017"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09238"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c08929"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28010070"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b01097"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00180"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00905"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.74276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.74276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:10:55Z","timestamp":1787083855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.74276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":50,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/smll.74276"],"URL":"https:\/\/doi.org\/10.1002\/smll.74276","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74276"}}