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Herein, a wearable hydrogel (Gel@COF), designed for the concurrent monitoring of dopamine levels and resting tremor to enable early PD detection and intervention, is reported. The Gel@COF is fabricated by encapsulating a covalent organic framework (COF\u2010101) functionalized with phenylboronic acid within a self\u2010crosslinked hydrogel. Notably, the COF\u2010101 features a unique fractal and heteroporous structure. The fractal morphology provides abundant dopamine recognition sites via the grafted phenylboronic acid, while the heteroporous structure significantly enhances proton conductivity. Thus, Gel@COF achieves high sensitivity at 1% strain and delivers a fast response\/recovery time of 16.0\u00a0ms. Furthermore, the unique topological structure of COF\u2010101 endows Gel@COF with visual fluorescence changes. After integrating a convolutional neural network algorithm with Gel@COF, its evaluation and prediction accuracy for PD was rapidly improved to over 95%. This dual\u2010functional wearable gel offers patients real\u2010time and convenient rehabilitation monitoring, demonstrating significant potential for translational applications.<\/jats:p>","DOI":"10.1002\/smll.74297","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:59:16Z","timestamp":1782478756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deep Learning Assisted Heteroporous Covalent Organic Framework Hydrogels Enable Dual\u2010Mode Tracking and Analysis to Parkinson's Management"],"prefix":"10.1002","volume":"22","author":[{"given":"Zemiao","family":"Gao","sequence":"first","affiliation":[{"name":"Heilongjiang Provincial Key Laboratory of Surface Active Agent and Auxiliary Chemistry and Chemical Engineering Institute Qiqihar University  Qiqihar 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